News tagged with drug development
Study IDs key protein for cell death, offers way to kill cancer cells by forcing them into programmed-death pathway
When cells suffer too much DNA damage, they are usually forced to undergo programmed cell death, or apoptosis. However, cancer cells often ignore these signals, flourishing even after chemotherapy drugs have ...
Genetics
May 14, 2013 |
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Scientists show how nerve wiring self-destructs
Many medical issues affect nerves, from injuries in car accidents and side effects of chemotherapy to glaucoma and multiple sclerosis. The common theme in these scenarios is destruction of nerve axons, the ...
Neuroscience
May 09, 2013 |
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Ethics experts call for more thoughtful optimization of drug development process
(Medical Xpress)—McGill University post-doctoral fellow Spencer Phillips Hey and Prof. Jonathan Kimmelman, Biomedical Ethics, Social Studies of Medicine, Faculty of Medicine argue that some clinical trials of new drugs ...
Medications
May 09, 2013 |
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Drug shows some benefit for kids with autism
(HealthDay)—An experimental drug for autism did not improve levels of lethargy and social withdrawal in children who took it, but it did show some other benefits, a new study finds.
Autism spectrum disorders
May 02, 2013 |
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Intractable seizures halted with experimental treatment for rare pediatric 'Pretzel syndrome'
With a better understanding of underlying mechanisms that cause a rare neurodevelopmental disorder in the Old Order Mennonite population, referred to as Pretzel syndrome, a new study reports that five children were successfully ...
Neuroscience
Apr 24, 2013 |
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Lab boost for precious anti-malaria drug
US scientists on Wednesday said they had used baker's yeast to make a key ingredient of malaria drugs, a feat that could iron out fluctuations in supply caused by sourcing the chemical from a Chinese herb.
Diseases, Conditions, Syndromes
Apr 10, 2013 |
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Researchers confirm multiple genes robustly contribute to schizophrenia risk in replication study
Multiple genes contribute to risk for schizophrenia and appear to function in pathways related to transmission of signals in the brain and immunity, according to an international study led by Virginia Commonwealth University ...
Genetics
Apr 09, 2013 |
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Canada loses out on drug pricing, study says
Health systems worldwide are increasingly negotiating secret price rebates from pharmaceutical companies and Canadians risk losing out on the deal.
Health
Apr 08, 2013 |
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Shutting down DNA construction: How senescence halts growth of potential cancers
Researchers from The Wistar Institute explain a new molecular mechanism behind the phenomenon of oncogene-induced senescence. By depriving the cell of the ability to make new nucleotides—the building blocks ...
Cancer
Apr 04, 2013 |
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New study explores role of social responsibility in drug development
(Medical Xpress)—Though pharmaceutical companies that are developing "orphan drugs" do so mainly for the business potential, the companies also consider the effort as part of their corporate social responsibility, ...
Medications
Apr 01, 2013 |
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New chemo drug gentler on fertility, tougher on cancer
A new gentler chemotherapy drug in the form of nanoparticles has been designed by Northwestern Medicine® scientists to be less toxic to a young woman's fertility but extra tough on cancer. This is the first cancer drug tested ...
Cancer
Mar 22, 2013 |
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Rules must evolve to allow new drugs for early Alzheimer's
(HealthDay)—Given the shift in the focus of drug development for Alzheimer's disease toward earlier disease stages, before the onset of dementia, regulatory guidelines need to evolve, according to a perspective ...
Alzheimer's disease & dementia
Mar 14, 2013 |
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Study links US mortality rates under age 50 to life expectancy lagging other high-income countries
(Medical Xpress)—Higher mortality rates among Americans younger than 50 are responsible for much of why life expectancy is lower in the United States than most of the world's most developed nations.
Health
Mar 12, 2013 |
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Accelerating drug development
All human clinical trials of new treatments begin with phase I, where drugs are tested in isolation to confirm their safety. Yet most effective cancer treatments use a combination of drugs, so-called 'multi-agent' ...
Medications
Mar 08, 2013 |
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Deworming important for children's health, has limited impact on infection in wider communities
Although they have an important impact on children's health and education, school-based deworming programmes have a limited impact on the level of infection in the wider community, according to a mathematical modeling study ...
Diseases, Conditions, Syndromes
Feb 28, 2013 |
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