News tagged with drug discovery
Continuous infusion of a novel agent not only halted the progression of Ewing sarcoma in rats, while some tumors also regressed to the point that cancer cells could not be detected microscopically, say researchers at Georgetown ...
Cancer May 15, 2013 | not rated yet | 0
Using a new stem-cell based drug screening technology with the potential to reinvent and greatly reduce the cost of the way new pharmaceuticals are developed, Harvard Stem Cell Institute (HSCI) researchers ...
Diseases, Conditions, Syndromes Apr 18, 2013 | 5 / 5 (2) | 0 |
An eight gene 'signature' can predict length of relapse-free survival after chemotherapy, finds new research in Biomed Central's open access journal BMC Medicine.
Cancer Apr 15, 2013 | not rated yet | 0
Scientists at The Scripps Research Institute (TSRI) have shed light on one of the major toxic mechanisms of Alzheimer's disease. The discoveries could lead to a much better understanding of the Alzheimer's process and how ...
Neuroscience Apr 10, 2013 | 5 / 5 (6) | 0 |
A new discovery about the malaria-related parasite Toxoplasma gondii—which can threaten babies, AIDS patients, the elderly and others with weakened immune function—may help solve the mystery of how th ...
Medical research Apr 08, 2013 | 4.3 / 5 (3) | 0 |
Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have developed a small molecule that inhibits STAT3, a protein that causes cancer. This development could impact the treatment of several ...
Cancer Mar 26, 2013 | 4.5 / 5 (2) | 0 |
(Medical Xpress)—Queensland Institute of Medical Research, Griffith University and University of Queensland scientists researching a degenerative brain disease have developed a new way to understand its progression and ...
Genetics Mar 22, 2013 | 5 / 5 (1) | 0 |
A seemingly obscure gene in the female fruit fly that is only active in cells that will become eggs has led researchers at the Stowers Institute for Medical Research to the discovery of a atypical protein ...
Cancer Mar 13, 2013 | 5 / 5 (3) | 0 |
An extract from a shrub often used for medicinal purposes in tropical Africa may have lethal effects against a dangerous parasite that transmits malaria, according to a multi-institutional team of scientists ...
Medical research Mar 08, 2013 | not rated yet | 0 |
(HealthDay)—Fraudulent health products are commonplace and can cause serious injury or even death, the U.S. Food and Drug Administration warns.
Medications Mar 06, 2013 | not rated yet | 0
Each time we use an antibiotic, the weaker strains of infection are killed off while the stronger, more virulent strains are left behind to multiply. In the past, this has not caused much concern, as there ...
Medications Feb 28, 2013 | not rated yet | 0
(Medical Xpress)—Researchers in Scotland and Germany have discovered a molecular mechanism that shows promise for developing a cure for Huntington's Disease (HD).
Neuroscience Feb 27, 2013 | 3 / 5 (1) | 0 |
A major new centre to boost the development of drugs to tackle the foremost diseases of the developing world is to be created at the University of Dundee.
Diseases, Conditions, Syndromes Feb 13, 2013 | not rated yet | 0
A team of scientists anchored at Yale University has demonstrated a new, highly versatile approach for quickly assembling drug-like compounds, establishing a broad new route to drug discovery and medical treatment. They report ...
Medications Feb 07, 2013 | 4 / 5 (1) | 0 |
Researchers at Sahlgrenska Academy in collaboration with Chalmers University of Technology developed a unique Bioactive3D culture system for brain cells. This system gives new possibilities to study cell-cell ...
Medical research Jan 25, 2013 | 5 / 5 (1) | 0
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed.
In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge.
The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.
Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, "expensive, difficult, and inefficient process" with low rate of new therapeutic discovery. Information on the human genome, its sequence and what it encodes has been hailed as a potential windfall for drug discovery, promising to virtually eliminate the bottleneck in therapeutic targets that has been one limiting factor on the rate of therapeutic discovery. However, data indicates that "new targets" as opposed to "established targets" are more prone to drug discovery project failure in general This data corroborates some thinking underlying a pharmaceutical industry trend beginning at the turn of the twenty-first century and continuing today which finds more risk aversion in target selection among multi-national pharmaceutical companies.
For more information about Drug discovery, read the full article at
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