Medical research

New computational method exploits the polypharmacology of drugs

(Medical Xpress)—If life were simple, a disease could be treated with one drug that hits one molecular target, like striking a piano key. Instead, researchers wrestle with the fact that most drugs hit multiple targets in ...

Oncology & Cancer

Depletion of 'traitor' immune cells slows cancer growth in mice

When a person has cancer, some of the cells in his or her body have changed and are growing uncontrollably. Most cancer drugs try to treat the disease by killing those fast-growing cells, but another approach called immunotherapy ...

Genetics

Study finds new genes behind severe childhood epilepsy

A large-scale international study on the genes involved in epilepsy has uncovered 25 new mutations on nine key genes behind a devastating form of the disorder during childhood. Among those were two genes never before associated ...

Neuroscience

Distinct brain disorders biologically linked

A team of researchers have shown that schizophrenia and a disorder associated with autism and learning difficulties share a common biological pathway. This is one of the first times that researchers have uncovered genetic ...

Alzheimer's disease & dementia

Key molecular pathways leading to Alzheimer's identified

Key molecular pathways that ultimately lead to late-onset Alzheimer's disease, the most common form of the disorder, have been identified by researchers at Columbia University Medical Center (CUMC). The study, which used ...

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