Pediatrics

New approach may prevent deadly intestinal disease in preemies

Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago and colleagues found that an investigational protein replacement—recombinant human insulin-like growth ...

Genetics

Discovery unravels the mystery of a rare bone disease

A McGill-led team of researchers has made an important discovery shedding light on the genetic basis of a rare skeletal disorder. The study, published in Nature Communications, reveals that a defect in a specific gene (heterozygous ...

Arthritis & Rheumatism

Joint replacement surgery, arthritis are not inevitable

Don't worry about your hips or knees as you age. Arthritis in those joints isn't inevitable. Keep doing the activities you enjoy. Those hopeful words come from Rafael Sierra, M.D., an orthopedic surgeon at Mayo Clinic specializing ...

Health

Researchers unlock predictive biomarkers for common hip disorder

Researchers from the University of Missouri School of Medicine have developed panels of protein biomarkers present in teens and young adults that distinguish individuals with healthy hips from those with developmental dysplasia ...

Obstetrics & gynaecology

How magnesium sulfate benefits preterm babies

Being born too soon exposes babies to many dangerous health conditions, and researchers are tackling one of them by finding out how magnesium sulfate can protect the health of the preterm brain.

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Dysplasia

Dysplasia (from the Greek δυσπλασία "malformation", δυσ- "mal-" + πλάθω "to create, to form"), is a term used in pathology to refer to an abnormality of development. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells. Dysplasia is often indicative of an early neoplastic process. The term dysplasia is typically used when the cellular abnormality is restricted to the originating tissue, as in the case of an early, in-situ neoplasm.

Dysplasia, in which cell maturation and differentiation are delayed, can be contrasted with metaplasia, in which cells of one mature, differentiated type are replaced by cells of another mature, differentiated type.

The terms hip dysplasia and fibrous dysplasia also refer to abnormal development, but at a more macroscopic level.

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