Leicester geneticists have discovered a potential defence against Huntington's disease – a fatal neurodegenerative disorder which currently has no cure.
Aug 25, 2013
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Researchers have created a new phenotypic screening platform that better predicts success of drugs developed to prevent blood vessel tumor growth when moving out of the lab and onto actual tumors.
Nov 13, 2011
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Scientists at the Francis Crick Institute have uncovered how a build-up of DNA molecules can impact survival chances in people with severe COVID-19 or sepsis, and have developed a tool that could be used to identify the patients ...
Nov 17, 2022
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A new study, published in Frontiers in Molecular Neuroscience, reveals how a rare genetic mutation leads to intellectual disability. The P212L mutation in an enzyme called CaMKIIalpha, which is important for learning and ...
Sep 1, 2022
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Pompe disease, a severe glycogen storage disease appearing in Lapphunds is caused by a genetic defect in acid α-glucosidase gene. The same genetic mutation also causes the equivalent disease in humans. Based on this finding, ...
Feb 15, 2013
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In Alzheimer's disease, plaques of amyloid beta protein accumulate in the brain, damaging connections between neurons. Now, researchers at University of California San Diego School of Medicine and Harvard Medical School have ...
May 10, 2016
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A team led by scientists at The Scripps Research Institute (TSRI) has identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare ...
Jan 12, 2015
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Like a car's front and back bumpers, your cell's chromosomes are capped by "telomeres" that protect this genetic material against deterioration. Still, after enough replications, a chromosome's telomeres break down and once ...
Feb 18, 2015
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Ruxolitinib, a drug that is already approved by the U.S. Food and Drug Administration (FDA) for treating certain cancers and skin conditions, is effective at inhibiting CaMKII, a protein kinase linked to cardiac arrhythmias.
Jun 21, 2023
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While in search of the causes of allergies and asthma, a chance discovery has yielded new clues: researchers led by Dr. Marcus Peters have ascertained that the enzyme guanylate cyclase in cells lays the foundations for the ...
Jul 23, 2018
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