News tagged with epidermal growth factor receptor
Related topics: patients , breast cancer , cancer , lung cancer , cancer cells
Signature of circulating breast tumor cells that spread to the brain found
Some breast tumor circulating cells in the bloodstream are marked by a constellation of biomarkers that identify them as those destined to seed the brain with a deadly spread of cancer, said researchers led by those at Baylor ...
Cancer
Apr 10, 2013 |
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A hijacking of healthy cellular circuits
Proteins that control cell growth are often mutated in cancer, and their aberrant signaling drives the wild proliferation of cells that gives rise to tumors. One such protein, the epidermal growth factor receptor (EGFR), ...
Cancer
Apr 08, 2013 |
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Certain breast cancer patients may benefit from combined HER2 targeted therapy without chemotherapy
Is the era of targeted therapy for breast cancer at hand? It could be, said experts at the Lester and Sue Smith Breast Center at Baylor College of Medicine – at least for a certain population of women.
Cancer
Apr 08, 2013 |
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Comparing combination therapies for advanced head and neck cancer shows no improvement
Locally advanced squamous cell carcinoma of the head and neck is a potentially curable disease in nearly every patient at the time of diagnosis, yet despite the most aggressive efforts, up to 30-50 percent ...
Cancer
Mar 07, 2013 |
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By determining structural effects of tumor-causing mutations, scientists obtain valuable information for drug discovery
(Medical Xpress)—For many patients with non-small-cell lung carcinoma (NSCLC), tumorigenesis is fueled by mutations that hyperactivate the epidermal growth factor receptor (EGFR) signaling protein. These ...
Cancer
Feb 15, 2013 |
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New details on the molecular machinery of cancer
Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor ...
Cancer
Feb 11, 2013 |
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Scientists find a new way to boost common cancer drugs
Shutting down a specific pathway in cancer cells appears to improve the ability of common drugs to wipe those cells out, according to new research from scientists at Fox Chase Cancer Center, published in the January issue ...
Cancer
Jan 14, 2013 |
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PR+ cells add prognostic value in luminal A breast cancer
(HealthDay)—Semiquantitative immunohistochemical expression of progesterone receptor-positive tumor cells improves prediction of survival within luminal A breast cancers, according to a study published ...
Cancer
Dec 17, 2012 |
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SABCS: no benefit in extending trastuzumab in HER2 breast CA
(HealthDay)—For patients with human epidermal growth factor receptor 2 (HER2)-positive early-stage breast cancer, one year of adjuvant trastuzumab should remain the standard of care, according to a study ...
Cancer
Dec 07, 2012 |
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Researchers identify gene involved in lung tumor growth
Lung cancer researchers at St. Joseph's Hospital and Medical Center in Phoenix, Ariz., in collaboration with researchers at the Translational Genomics Research Institute and other institutions, have identified a gene that ...
Cancer
Nov 29, 2012 |
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Heart failure in older breast cancer patients linked to medication
Heart failure is a relatively common complication in older women with breast cancer, but the risk is even higher in those patients treated with adjuvant trastuzumab (Herceptin), Yale School of Medicine researchers report ...
Cardiology
Nov 14, 2012 |
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New finding gives clues for overcoming tamoxifen-resistant breast cancer
(Medical Xpress)—A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients ...
Cancer
Nov 02, 2012 |
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Adverse prognostic factor ID'd in operable breast cancer
(HealthDay)—For women with operable breast cancer, moderate immunohistochemical expression of human epidermal growth factor receptor (HER)-2 (2+) without amplification of HER-2 (HER-2 2+/HER-2−) is an adverse prognostic ...
Cancer
Oct 30, 2012 |
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Scientists reverse Alzheimer's-like memory loss in animal models by blocking EGFR signaling
A team of neuroscientists and chemists from the U.S. and China today publish research suggesting that a class of currently used anti-cancer drugs as well as several previously untested synthetic compounds show effectiveness ...
Alzheimer's disease & dementia
Sep 24, 2012 |
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PARP inhibitors may have clinical utility in HER2-positive breast cancers
Poly (ADP-Ribose) polymerase (PARP) inhibitors, shown to have clinical activity when used alone in women with familial breast and ovarian cancers linked to BRCA mutations, may be a novel treatment strategy in women with HER2-positive ...
Cancer
Sep 17, 2012 |
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