Pediatrics

Certain macrolides linked with higher risk of pyloric stenosis

(HealthDay)—New research supports previous findings that erythromycin can increase the risk of infantile hypertrophic pyloric stenosis (IHPS). The research also indicates that azithromycin is associated with a higher risk ...

Diseases, Conditions, Syndromes

Antibiotic may provide benefit for treatment of respiratory disorder

Among patients with the lung disorder non-cystic fibrosis bronchiectasis, treatment with the antibiotic erythromycin resulted in improvement in symptoms but also increased the risk of antibiotic resistance, according to a ...

Diseases, Conditions, Syndromes

Emerging antibiotic resistance in Listeria

Malaysian researchers have revealed the presence of multidrug-resistant strains of Listeria monocytogenes in frozen burger patties taken from supermarkets and other retail shops in Malaysia. The research was published in ...

Erythromycin

Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma and Legionellosis. It was first marketed by Eli Lilly and Company, and it is today commonly known as EES (erythromycin ethylsuccinate, an ester prodrug that is commonly administered).

In structure, this macrocyclic compound contains a 14-membered lactone ring with ten asymmetric centers and two sugars (L-cladinose and D-desosamine), making it a compound very difficult to produce via synthetic methods.

Erythromycin is produced from a strain of the actinomycete Saccharopolyspora erythraea.

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