Diseases, Conditions, Syndromes

Breakthroughs and challenges in fungal vaccine development

The microbiological world is comprised of many organisms, including bacteria, viruses, and fungi. Though not generally regarded as pathogens by the greater public, fungi can cause an array of severe diseases, especially in ...

Medical research

Targeting autophagy to enhance memory immune responses

Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Researchers from Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances ...

Immunology

Molecular component of caffeine may play a role in gut health

Brigham researchers studying how and why certain cell types proliferate in the gut found that xanthine, which is found in coffee, tea and chocolate, may play a role in Th17 differentiation. Insights may help investigators ...

Medical research

Exploring how fungal spores hijack lung cells

The pathogenic fungus Aspergillus fumigatus escapes elimination from surface cells of the human lung by binding to a human protein. In doing so, it is able to nest in so called phagosomes, confined areas in the lung cells, ...

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