News tagged with g proteins
Finding a family for a pair of orphan receptors in the brain
Researchers at Emory University have identified a protein that stimulates a pair of "orphan receptors" found in the brain, solving a long-standing biological puzzle and possibly leading to future treatments for neurological ...
Medical research
May 21, 2013 |
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Scientists provide detailed view of brain protein structure: Results may help improve drugs for neurological disorders
Researchers have published the first highly detailed description of how neurotensin, a neuropeptide hormone which modulates nerve cell activity in the brain, interacts with its receptor. Their results suggest that neuropeptide ...
Medical research
Oct 10, 2012 |
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Structure of vital protein complex, G protein-coupled receptors, described in unprecedented detail
Three international teams of scientists, led by researchers at the University of California San Diego, University of Michigan and Stanford University, have published a trio of papers describing in unprecedented ...
Medical research
Sep 28, 2011 |
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Scientists create molecular map to guide treatment of multiple sclerosis
A team of scientists from the Scripps Research Institute, collaborating with members of the drug discovery company Receptos, has created the first high-resolution virtual image of cellular structures called ...
Medical research
Feb 16, 2012 |
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Cellular gatekeepers do more than open doors for drugs, study finds
(Medical Xpress)—The cellular gatekeepers that escort the most common pharmaceuticals into our cells continue to work within the cells as well, according to a UC San Francisco discovery that could transform drug design ...
Medical research
Apr 08, 2013 |
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Study reveals how serotonin receptors can shape drug effects from LSD to migraine medication
A team including scientists from The Scripps Research Institute (TSRI), the University of North Carolina at Chapel Hill and the Chinese Academy of Sciences has determined and analyzed the high-resolution ...
Medical research
Mar 21, 2013 |
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Researchers discover key to heart failure, new therapies on horizon
Some 5.8 million Americans suffer from heart failure, a currently incurable disease. But scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine have discovered a key biochemical step ...
Medical research
Mar 05, 2013 |
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Signaling pathway linked to fetal alcohol risk: Molecular switch promises new targets for diagnosis, therapy
Fetal alcohol syndrome is the leading preventable cause of developmental disorders in developed countries. And fetal alcohol spectrum disorder (FASD), a range of alcohol-related birth defects that includes fetal alcohol syndrome, ...
Medical research
Feb 20, 2013 |
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Researchers pave the way for improving treatment for Type 2 diabetes
In a study published last week in the prestigious Proceedings of the National Academy of Sciences of the United States of America, a team led by Dr. Vincent Poitout of the University of Montreal Hospital Research Centre (CRCHU ...
Diabetes
Feb 07, 2012 |
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Popular antidepressant might prevent heart failure
A medication usually used to help treat depression and anxiety disorders has the potential to help prevent heart failure, according to researchers at the University of Michigan.
Medications
Oct 01, 2012 |
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Rap1 plays role in smooth muscle cell vasoconstriction
(HealthDay) -- The Ras-related small GTPase, Rap1, couples to RhoA, and is involved in relocalization of G protein-coupled α2C-adrenoceptors (α2CARs) in smooth muscle cells derived from human de ...
Medical research
Aug 06, 2012 |
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G proteins regulate remodelling of blood vessels
Blood vessels are extremely dynamic: depending on the external conditions, they can adapt their permeability for nutrients, their contractility, and even their shape. Unlike cardiac muscle cells, for example, ...
Medical research
Nov 13, 2012 |
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Improving obesity-induced insulin sensitivity
In recent years, a growing body of evidence has linked inflammation to the development of insulin resistance. In insulin resistance, the hormone insulin is less effective in promoting glucose uptake from the bloodstream into ...
Overweight and Obesity
Jun 01, 2012 |
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Study identifies potential new pathway for drug development
A newly found understanding of receptor signaling may have revealed a better way to design drugs. A study from Nationwide Children's Hospital suggests that a newly identified group of proteins, alpha arrestins, may play a ...
Medical research
Dec 10, 2012 |
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Common drugs initiate a molecular pas de quatre at the surface of the cell membrane
G protein-coupled receptors (GPCRs) are popular drug targets, accounting for about one-third of approved drugs and many hundreds of drugs currently in development. They act as molecular switches that transduce extracellular ...
Medical research
Jul 26, 2011 |
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