Opioids are powerful painkillers, but their use is hindered because patients become tolerant to them, requiring higher and higher doses, and overdoses can cause respiratory depression and death. A recent study from researchers ...
Aug 24, 2021
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Pharmacologists are working to help mitigate the detrimental side effects of opiates, including addiction, respiratory depression, constipation and alcohol use. Many pharmacologists are doing this by developing drugs that ...
Aug 11, 2021
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Researchers from the G-protein-coupled receptor-based drug development research group at the Hospital del Mar Medical Research Institute (IMIM) have been able to verify, with a degree of precision never before achieved, ...
Jul 29, 2021
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Serotonin (5-HT), one of the primary hormones released in the human brain, has many essential functions. For instance, serotonin is known to stabilize the mood, produce feelings of well-being, regulate sleep patterns and ...
Researchers from Hefei University of Technology in China have recently published an exhaustive review in the Journal of Medicinal Chemistry on emerging roles of small kinase inhibitors in the treatment of diseases. In contrast ...
Scientists at Scripps Research have clarified the workings of a mysterious protein called Gαo, which is one of the most abundant proteins in the brain and, when mutated, causes severe movement disorders.
Feb 3, 2021
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G protein-coupled receptors (GPCRs) are the largest family of membrane protein receptors. The proteins control how tissues and organs function. More than one-third of current drugs target these receptors.
Nov 5, 2020
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People who survive serious COVID-19 infections have long-lasting immune responses against the virus, according to a new study led by researchers at Massachusetts General Hospital (MGH). The study, published in Science Immunology, ...
Oct 8, 2020
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Scientists at Scripps Research have comprehensively mapped how a key class of proteins within cells regulates signals coming in from cell surface receptors.
Oct 2, 2020
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Duke University researchers have developed a synthetic molecule that selectively dampen the physiological rewards of cocaine in mice. It also may represent a new class of drugs that could be more specific with fewer side ...
May 28, 2020
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