Scientists find clues to some inherited heart diseases
(Medical Xpress)—Cornell researchers have uncovered the basic cell biology that helps explain heart defects found in diseases known as laminopathies, a group of some 15 genetic disorders that include forms ...
Medical research
May 07, 2013 |
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Comparing mouse and human immune systems: Few differences charted in map to translate mouse findings to humans
(Medical Xpress)—It is a familiar note struck when authors conclude their reports on experiments conducted in mouse models: They suggest caution when translating their findings from mouse to human. A variation ...
Medical research
Apr 02, 2013 |
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Mouse models fail to reproduce inflammatory genomic response to serious injuries
Existing mouse models do not appear to accurately reproduce the human genomic response to serious traumatic injury, including major burns, according to an article appearing in PNAS Early Edition.
Inflammatory disorders
Feb 11, 2013 |
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New technique comprehensively generates three-dimensional maps of gene expression in the brain
A research team led by Yuko Okamura-Oho and Hideo Yokota of the RIKEN Advanced Science Institute, Wako, has developed a novel technique for three-dimensional (3D) mapping of gene expression patterns onto ...
Genetics
Jan 11, 2013 |
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Two heads are better than one: Gene expression reveals molecular mechanisms underlying evolution of cerebral cortex
Dramatic expansion of the human cerebral cortex, over the course of evolution, accommodated new areas for specialized cognitive function, including language. Understanding the genetic mechanisms underlying ...
Neuroscience
Nov 09, 2012 |
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Tumor-causing cells are squishier, study finds
(Medical Xpress)—A new tool developed by scientists at The Methodist Hospital separates tumor-causing cancer cells from more benign cells by subjecting the cells to a microscopic game of Plinko—except only the squishiest ...
Cancer
Nov 05, 2012 |
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Making sense out of the biological matrix of bipolar disorder
The more that we understand the brain, the more complex it becomes. The same can be said about the genetics and neurobiology of psychiatric disorders. For "Mendelian" disorders, like Huntington disease, mutation of a single ...
Psychology & Psychiatry
Aug 20, 2012 |
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Highlighting molecular clues to the link between childhood maltreatment and later suicide
Exposure to childhood maltreatment increases the risk for most psychiatric disorders as well as many negative consequences of these conditions. This new study, by Dr. Gustavo Turecki and colleagues at McGill University, Canada, ...
Psychology & Psychiatry
Jul 03, 2012 |
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Study identifies genes linked to resistance to breast cancer chemotherapy
A study led by Vanderbilt-Ingram Cancer Center (VICC) investigators has identified a gene expression pattern that may explain why chemotherapy prior to surgery isn't effective against some tumors and suggests new therapy ...
Cancer
Jun 11, 2012 |
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Fish show autism-like gene expression in water with psychoactive pharmaceuticals
Psychoactive medications in water affect the gene expression profiles of fathead minnows in a way that mimics the gene expression patterns associated with autism spectrum disorder in genetically susceptible humans, according ...
Autism spectrum disorders
Jun 06, 2012 |
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Molecular subtypes and genetic alterations may determine response to lung cancer therapy
Cancer therapies targeting specific molecular subtypes of the disease allow physicians to tailor treatment to a patient's individual molecular profile. But scientists are finding that in many types of cancer the molecular ...
Cancer
May 11, 2012 |
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Gene signature helps identify risk of relapse in lung cancer patients
A new genetic signature identified by Spanish researchers may provide doctors with robust and objective information about which patients with early stage lung cancer are at low or high risk of relapse following surgery, investigators ...
Cancer
Apr 18, 2012 |
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Researchers reveal digital transcriptome of breast cancer
GW Cancer Research Team in the Department of Biochemistry and Molecular Biology, in the School of Medicine and Health Sciences, published a study that is the first of its kind to use mRNA sequencing to look at the expression ...
Cancer
Feb 14, 2012 |
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A gene for depression localized
Psychiatric disorders can be described on many levels, the most traditional of which are subjective descriptions of the experience of being depressed and the use of rating scales that quantify depressive symptoms. Over the ...
Psychology & Psychiatry
Jan 04, 2012 |
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Traumatic injury sets off a 'genomic storm' in immune system pathways
Serious traumatic injuries, including major burns, set off a "genomic storm" in human immune cells, altering around 80 percent of the cells' normal gene expression patterns. In a report to appear in the December Journal of ...
Medical research
Dec 07, 2011 |
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