Scientists uncover novel mechanism of glioblastoma development
Most research on glioblastoma development, a complicated tumor of the brain with a poor prognosis, has focused on the gene transcription level, but scientists suggest that post-transcriptional regulation could be equally ...
Cancer
Jan 18, 2012 |
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Research team discovers genes and disease mechanisms behind a common form of muscular dystrophy
Continuing a series of groundbreaking discoveries begun in 2010 about the genetic causes of the third most common form of inherited muscular dystrophy, an international team of researchers led by a scientist at Fred Hutchinson ...
Cancer
Jan 12, 2012 |
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Signaling to chromatin
(Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research (FMI) in collaboration with their colleagues from the Department of Biosystems Science and Engineering of the ETH ...
Genetics
Jan 03, 2012 |
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Newly identified gene mutation adds to melanoma risk
A major international study has identified a novel gene mutation that appears to increase the risk of both inherited and sporadic cases of malignant melanoma, the most deadly form of skin cancer. The identified mutation occurs ...
Cancer
Nov 13, 2011 |
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Non-coding RNA relocates genes when it's time to go to work
Cells develop and thrive by turning genes on and off as needed in a precise pattern, a process known as regulated gene transcription. In a paper published in the Nov. 9 issue of the Journal of Neuroscience, researchers at the ...
Neuroscience
Nov 10, 2011 |
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'If Hamlet give the first or second hit': The development of Burkitt's lymphoma
The human c-myc gene encodes a transcription factor (MYC) involved in the regulation of a vast number of other genes – it has been estimated that the transcription of about one in six genes is somehow under the control ...
Cancer
Nov 08, 2011 |
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How major signaling pathways are wired to our genome gives new insight into disease processes
Whitehead Institute scientists have determined that master transcription factors determine the genes regulated by key signaling pathways. In this way, signaling pathways are targeted to genes that are most relevant to each ...
Medical research
Oct 27, 2011 |
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Language-related gene responsible for branching of neurons
(Medical Xpress) -- Which genetic mutations enabled the evolution of language? The foxp2 gene plays an important role in language development. Simon E. Fisher at the Max Planck Institute for Psycholinguistics in Nijmegen, ...
Genetics
Sep 01, 2011 |
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Breakthrough in genetics of fibroids
Uterine leiomyomas, also called fibroids, cause a very significant burden to women's health. They are benign tumors that occur in 60% of women by the age of 45 years and cause symptoms such as abdominal pain and discomfort, ...
Medical research
Aug 25, 2011 |
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Defect in A20 gene expression causes rheumatoid arthritis
Researchers from VIB (Flanders Institute for Biotechnology) and Ghent University have shown that a defective gene can contribute to the onset of rheumatoid arthritis, an often-crippling inflammation of the joints that afflicts ...
Genetics
Aug 16, 2011 |
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The unfolding 'SAGA' of transcriptional co-activators
Successful gene expression requires the concerted action of a host of regulatory factors. Long overshadowed by bonafide transcription factors, coactivators—the hanger-ons that facilitate transcription by docking onto ...
Genetics
Jul 14, 2011 |
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Transcription factor is potential target for liver cancer treatment
Altering the body's metabolism could be an effective treatment for deadly liver cancer, researchers report.
Cancer
Jul 06, 2011 |
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The good, the bad and the ugly: The many roles of c-JUN in cancer
The process of cell division is tightly regulated, as mistakes may lead to cancer. The so-called c-JUN protein has been fingered as causing tumors in both skin and liver. The group of Veronika Sexl at the University of Veterinary ...
Cancer
Jun 28, 2011 |
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Scientists find link between master gene and neurodegenerative disorders
Garbage comes in all shapes and sizes. Cells, the body's functional units of life, also produce 'garbage' - debris and dysfunctional elements the body must get rid of. Failure to dispose of this garbage could ...
Genetics
Jun 24, 2011 |
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In the lab and clinic, researchers develop a new therapy for blood cancers
Clinical researchers at VCU Massey Cancer Center have successfully completed a Phase I clinical trial evaluating a combination of the drugs Bortezomib and Alvocidib in patients with relapsed or refractory blood cancers, paving ...
Cancer
Jun 02, 2011 |
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