For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, ...
Feb 10, 2021
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Twenty years ago this month, the first draft of the human genome was publicly released. One of the major surprises that came from that project was the revelation that only 1.5 percent of the human genome consists of protein-coding ...
Feb 3, 2021
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Genome-wide association studies (GWAS) have typically excluded diverse and minority individuals in the search for gene variants that confer risk of disease. Researchers at Massachusetts General Hospital (MGH), the Broad Institute ...
Feb 2, 2021
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Genetics has made huge strides over the past 20 years, from the sequencing of the human genome to a growing understanding of factors that turn genes on and off, namely transcription factors and the DNA "enhancer" sequences ...
Dec 22, 2020
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Fractured sleep, daytime sleepiness and other signs of disturbance in one's circadian rhythm are common complaints of people with Alzheimer's disease, and the problems only get worse as the disease progresses. But the reason ...
Dec 16, 2020
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Potential treatments for COVID-19 have been identified after the discovery of five genes associated with the most severe form of the disease.
Dec 11, 2020
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Late-onset Alzheimer's disease (LOAD) is the most common form of dementia in the elderly, affecting almost 44 million people worldwide. Despite decades of research, genetic factors that predispose individuals to LOAD are ...
Dec 8, 2020
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More than a dozen drugs are known to treat symptoms such as hallucinations, erratic behaviors, disordered thinking and emotional extremes associated with schizophrenia, bipolar disorder and other severe mental illnesses. ...
Dec 3, 2020
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Researchers at the Estonian Genome Center at the University of Tartu have described hitherto undiscovered associations between miscarriage and maternal genes. They have published their findings in Nature Communications.
Nov 25, 2020
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The functional genomics field, which looks at the activities of the genome and levels of gene expression rather than particular gene mutations, generally relies on aggregating information from many samples for its statistical ...
Nov 12, 2020
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