News tagged with genetic alterations

New view of tumors' evolution

Cancer cells undergo extensive genetic alterations as they grow and spread through the body. Some of these mutations, known as "drivers," help spur cells to grow out of control, while others ("passengers") are merely along ...

Mar 13, 2014
popularity 5 / 5 (7) | comments 0

Distinct molecular subtype of prostate cancer identified

A collaborative expedition into the deep genetics of prostate cancer has uncovered a distinct subtype of the disease, one that appears to account for up to 15 percent of all cases, say researchers at Weill Cornell Medical ...

May 20, 2012
popularity 5 / 5 (1) | comments 0 | with audio podcast

Severe hypoglycemia cause identified

Cambridge scientists have identified the cause of a rare, life-threatening form of hypoglycaemia. Their findings, which have the potential to lead to pharmaceutical treatments for the disorder, were published today in the ...

Oct 06, 2011
popularity not rated yet | comments 0 | with audio podcast

New evidence for genetic basis of autism found

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered that one of the most common genetic alterations in autism -- deletion of a 27-gene cluster on chromosome 16 -- causes autism-like features. ...

Oct 03, 2011
popularity 4.3 / 5 (9) | comments 6 | with audio podcast

Hopkins team discovers how DNA changes

Using human kidney cells and brain tissue from adult mice, Johns Hopkins scientists have uncovered the sequence of steps that makes normally stable DNA undergo the crucial chemical changes implicated in cancers, psychiatric ...

Apr 14, 2011
popularity 5 / 5 (1) | comments 0 | with audio podcast

Lifestyle influences metabolism via DNA methylation

An unhealthy lifestyle leaves traces in the DNA. These may have specific effects on metabolism, causing organ damage or disease. Scientists of Helmholtz Zentrum München have now identified 28 DNA alterations associated with ...

Sep 20, 2013
popularity 4.7 / 5 (3) | comments 0 | with audio podcast

Clinical trials for cancer, one patient at a time

Columbia University Medical Center (CUMC) researchers are developing a new approach to cancer clinical trials, in which therapies are designed and tested one patient at a time. The patient's tumor is "reverse ...

Jul 15, 2013
popularity 3.7 / 5 (3) | comments 1 | with audio podcast