News tagged with genetic model
Team creates a unique mouse model for the study of aplastic anaemia
Aplastic anaemia is characterised by a reduction in the number of the bone marrow cells that go on to form the different cell types present in blood (essentially red blood cells, white blood cells and platelets). In most ...
Medical research
Aug 29, 2012 |
not rated yet |
0
New model of muscular dystrophy provides insight into disease development
Muscular dystrophy is a complicated set of genetic diseases in which genetic mutations affect the various proteins that contribute to a complex that is required for a structural bridge between muscle cells and the extracellular ...
Medical research
Aug 27, 2012 |
5 / 5 (1) |
0
Low oxygen boosts stem cell survival in muscular dystrophy therapy
(Medical Xpress) -- Controlling the amount of oxygen that stem cells are exposed to can significantly increase the effectiveness of a procedure meant to combat an often fatal form of muscular dystrophy, according ...
Medical research
Aug 21, 2012 |
not rated yet |
0
|
Low oxygen levels may decrease life-saving protein in spinal muscular atrophy
Investigators at Nationwide Children's Hospital may have discovered a biological explanation for why low levels of oxygen advance spinal muscular atrophy (SMA) symptoms and why breathing treatments help SMA patients live ...
Genetics
Aug 21, 2012 |
not rated yet |
0
|
Discovery of immune cells that protect against multiple sclerosis offers hope for new treatment
In multiple sclerosis, the immune system attacks nerves in the brain and spinal cord, causing movement problems, muscle weakness and loss of vision. Immune cells called dendritic cells, which were previously thought to contribute ...
Immunology
Aug 16, 2012 |
not rated yet |
0
|
Team introduces new method to closely model diseases caused by splicing defects
A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases – those with pathology caused by errors in the splicing of ...
Genetics
Aug 14, 2012 |
4.5 / 5 (2) |
0
|
Gene therapy holds promise for reversing congenital hearing loss
A new gene therapy approach can reverse hearing loss caused by a genetic defect in a mouse model of congenital deafness, according to a preclinical study published by Cell Press in the July 26 issue of the journal Neuron. The fi ...
Neuroscience
Jul 25, 2012 |
4 / 5 (3) |
0
|
Preclinical data support ongoing clinical trials testing IDO inhibitors as a treatment for cancer
Inhibitors of indoleamine 2,3-dioxygenase (IDO) are being assessed in clinical trials as a potential treatment for recurrent or refractory solid tumors. Clear genetic rationale for these trials, together with evidence that ...
Cancer
Jul 19, 2012 |
not rated yet |
0
Preclinical development shows promise to treat hearing loss with Usher syndrome III
A new study published in the July 11 issue of the Journal of Neuroscience details the development of the first mouse model engineered to carry the most common mutation in Usher syndrome III causative gene (Clarin-1) in Nor ...
Neuroscience
Jul 10, 2012 |
not rated yet |
0
|
Cell differentiation as a novel strategy for the treatment of an aggressive type of skin cancer
Skin squamous cell carcinoma (SCC) is a subtype of very aggressive skin cancers that usually develops in sunexposed body regions, but can also affect a large number of organs such as the bladder, esophagus, lungs etc. However, ...
Cancer
Jul 09, 2012 |
not rated yet |
0
Scientists develop mouse model that could lead to new therapies for liver cancer
Researchers have created the first mouse model demonstrating the role of a cancer promoting gene, Astrocyte elevated gene-1 (AEG-1), in hepatocellular carcinoma, or liver cancer. The mouse model represents a critical step ...
Cancer
Jul 06, 2012 |
not rated yet |
0
Zebrafish provide insights into causes and treatment of human diseases
Zebrafish, popular as aquarium fish, now have an important place in research labs as a model organism for studying human diseases.
Genetics
Jul 06, 2012 |
not rated yet |
1
Cystic fibrosis makes airways more acidic, reduces bacterial killing
The human airway is a pretty inhospitable place for microbes. There are numerous immune defense mechanisms poised to kill or remove inhaled bacteria before they can cause problems. But cystic fibrosis (CF) disrupts these ...
Medical research
Jul 04, 2012 |
4.5 / 5 (4) |
0
|
Scientists correct Huntington's disease mutation in induced pluripotent stem cells
Johns Hopkins researchers, working with an international consortium, say they have generated stem cells from skin cells from a person with a severe, early-onset form of Huntington's disease (HD), and turned them into neurons ...
Medical research
Jun 28, 2012 |
5 / 5 (2) |
0
|
New compound holds promise for treating Duchenne MD, other inherited diseases
Scientists at UCLA have identified a new compound that could treat certain types of genetic disorders in muscles. It is a big first step in what they hope will lead to human clinical trials for Duchenne muscular dystrophy.
Genetics
Jun 27, 2012 |
not rated yet |
0
