News tagged with genetic pathways
Chemo may get boost from cholesterol-related drug
Johns Hopkins investigators are testing a way to use drugs that target a cholesterol pathway to enhance the cancer-killing potential of standard chemotherapy drugs. Their tests, in mouse models of pancreatic cancer, may yield ...
Cancer
Apr 03, 2012 |
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New genetic path for scleroderma: Patient biopsies reveal potential new target for therapy
A genetic pathway previously known for its role in embryonic development and cancer has been identified as a target for systemic sclerosis, or scleroderma, therapy. The finding, discovered by a cross-disciplinary team led ...
Arthritis & Rheumatism
Mar 19, 2012 |
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BIM gene variation in East Asians found to explain resistance to cancer drugs
A multi-national research team led by scientists at Duke-NUS Graduate Medical School has identified the reason why some patients fail to respond to some of the most successful cancer drugs.
Cancer
Mar 18, 2012 |
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PCP genetic pathway acts as stop sign for cell growth
The genetic pathway that regulates the way cells align themselves relative to each other has been found to act as a "stop sign" that signals organisms when to halt cell growth, according to new research published ...
Medical research
Mar 15, 2012 |
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Epigenetics and epidemiology -- hip, hype and science
Epigenetics is the new hip science. Time Magazine's front cover and article, 'Why your DNA isn't your Destiny' from January 2010 explains why. Its more explicit subtitle provided the hook - 'The new science of epigenetics ...
Genetics
Mar 15, 2012 |
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A new approach to faster anticancer drug discovery
Tracking the genetic pathway of a disease offers a powerful, new approach to drug discovery, according to scientists at the University of California, San Diego School of Medicine who used the approach to uncover a potential ...
Cancer
Mar 13, 2012 |
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Researchers find 5 risk biomarkers for Crohn's disease in Jews of Eastern European descent
In the largest study of its kind, researchers from Mount Sinai School of Medicine have discovered five new genetic mutations associated with Crohn's disease in Jews of Eastern European descent, also known as Ashkenazi Jews. ...
Genetics
Mar 08, 2012 |
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Neurobiologists identify animal model for a deadly human metabolic disorder
In medical research, finding a reliable and cost-effective animal model can greatly enhance success in identifying disease mechanisms and genetic pathways, potentially cutting years off drug testing regimes and development ...
Neuroscience
Feb 13, 2012 |
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Jak of all trades? Not of leukaemia therapy
About one in five or six cases of adult leukaemia in Western populations relates to so-called chronic myeloid leukaemia, or CML. Treatment of CML usually relies on inhibitors of the abnormal protein that causes the condition ...
Cancer
Jan 30, 2012 |
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Gene research sheds light on timing of menopause
(Medical Xpress) -- An international team of researchers has discovered 13 new regions of the genome associated with the timing of menopause.
Genetics
Jan 23, 2012 |
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Signaling to chromatin
(Medical Xpress) -- Scientists from the Friedrich Miescher Institute for Biomedical Research (FMI) in collaboration with their colleagues from the Department of Biosystems Science and Engineering of the ETH ...
Genetics
Jan 03, 2012 |
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Is obesity a ciliopathy, triggered by malfunctioning primary cilia?
Is obesity a ciliopathy, a disorder such as polycystic kidney disease (PKD), which is triggered by a defect in the microscopic hair-like cilia that protrude from virtually every cell of humans and other vertebrates?
Medical research
Dec 06, 2011 |
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Unlocking the genetic and molecular mystery of soft-tissue sarcoma
Scientists at Joslin Diabetes Center in Boston have uncovered important molecular and genetic keys to the development of soft-tissue sarcomas in skeletal muscle, giving researchers and clinicians additional targets to stop ...
Cancer
Nov 30, 2011 |
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Cleft lip corrected genetically in mouse model
Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research breakthrough may show the way ...
Genetics
Nov 28, 2011 |
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Surprising pathway implicated in stuttering
Researchers at Washington University School of Medicine in St. Louis have obtained new evidence that at least some persistent stuttering is caused by mutations in a gene governing not speech, but a metabolic pathway involved ...
Genetics
Nov 22, 2011 |
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