News tagged with genotyping
Investigators have identified a human chromosome containing a specific gene associated with susceptibility to herpes simplex labialis (HSL), the common cold sore. Published in the Journal of Infectious Diseases and now av ...
Diseases, Conditions, Syndromes Oct 28, 2011 | 4.8 / 5 (5) | 0 |
Scientists have discovered that a gene that influences empathy, parental sensitivity and sociability is so powerful that even strangers observing 20 seconds of silent video identified people with a particular genetic variation ...
Genetics Nov 14, 2011 | 5 / 5 (3) | 2 |
Lost in the euphoria of the 2003 announcement that the human genome had been sequenced was a fundamental question: how can we be sure that an individual's genome has been read correctly?
Genetics Feb 03, 2012 | 5 / 5 (3) | 0
With a 95 percent genomic similarity to humans, mice have long been used to learn about the genetic causes of human disease. Once researchers can shine a light on the genetic factors that cause disease in mice, they can start ...
Genetics Apr 05, 2012 | 5 / 5 (3) | 0 |
(Medical Xpress)—A new study out today reveals that the emergence and spread of a rapidly evolving invasive intestinal disease, that has a significant mortality rate (up to 45%) in infected people in sub-Saharan ...
Genetics Sep 30, 2012 | 5 / 5 (3) | 1 |
Since the 1930s scientists have proposed food restriction as a way to extend life in mice. Though feeding a reduced-calorie diet has indeed lengthened the life spans of mice, rats and many other species, new ...
Medical research May 03, 2011 | 4.3 / 5 (3) | 0 |
Can pregnant women help boost their children's brainpower by eating fish? The findings of a study, presented in the American Journal of Clinical Nutrition, show how children born to women who consumed more f ...
Health Jan 10, 2012 | 3 / 5 (4) | 0
New research shows that more than 75 per cent of people with a particular version of a gene don't produce under-arm odour but use deodorant anyway.
Health Jan 17, 2013 | 5 / 5 (2) | 6
Pediatric rotavirus vaccination also indirectly protects unvaccinated adults from the highly contagious cause of severe diarrhea and vomiting, suggests a new study published in Clinical Infectious Diseases and available online ...
Diseases, Conditions, Syndromes Jan 24, 2013 | 5 / 5 (2) | 0
A new study from the Centre for Addiction and Mental Health has found evidence that a specific gene is linked to suicidal behaviour, adding to our knowledge of the many complex causes of suicide. This research may help doctors ...
Psychology & Psychiatry Oct 07, 2011 | 5 / 5 (1) | 1
The active ingredient boceprevir has been available since the middle of 2011 as a treatment for chronic hepatitis C of genotype 1. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal ...
Diseases, Conditions, Syndromes Dec 09, 2011 | 5 / 5 (1) | 0
(HealthDay) -- Genotype at the A118G polymorphism of the µ-opioid receptor gene is associated with breast cancer-specific mortality, according to a study published in the April issue of Anesthesiology.
Cancer Mar 30, 2012 | 5 / 5 (1) | 0
Have you ever wondered why some people find it so much easier to stop smoking than others? New research shows that vulnerability to smoking addiction is shaped by our genes.
Genetics Sep 11, 2012 | 5 / 5 (1) | 0 |
A gene so powerful it nearly triples the risk of Alzheimer's disease has been discovered by an international team including researchers from Mayo Clinic. It is the most potent genetic risk factor for Alzheimer's identified ...
Alzheimer's disease & dementia Nov 14, 2012 | 5 / 5 (1) | 0 |
(Medical Xpress)—Platelet disorders are heavily underdiagnosed, little understood and cannot be cured. University of Birmingham researchers and the Birmingham Platelet Group are running a UK-wide clinical trial 'Genotyping ...
Medical research Feb 11, 2013 | 5 / 5 (1) | 0 |
Genotyping is the process of determining differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence using biological assays and comparing it to another individual's sequence or a reference sequence. It reveals the alleles an individual has inherited from their parents . Traditionally genotyping is the use of DNA sequences to define biological populations by use of molecular tools. It does not usually involve defining the genes of an individual.
Current methods of genotyping include restriction fragment length polymorphism identification (RFLPI) of genomic DNA, random amplified polymorphic detection (RAPD) of genomic DNA, amplified fragment length polymorphism detection (AFLPD), polymerase chain reaction (PCR), DNA sequencing, allele specific oligonucleotide (ASO) probes, and hybridization to DNA microarrays or beads. Genotyping is important in research of genes and gene variants associated with disease. Due to current technological limitations, almost all genotyping is partial. That is, only a small fraction of an individual’s genotype is determined. New mass-sequencing technologies promise to provide whole-genome genotyping (or whole genome sequencing) in the future.
Genotyping applies to a broad range of individuals, including microorganisms. For example, viruses and bacteria can be genotyped. Genotyping in this context may help in controlling the spreading of pathogens, by tracing the origin of outbreaks. This area is often referred to as molecular epidemiology or forensic microbiology.
Humans can also be genotyped. For example, when testing fatherhood or motherhood, scientists typically only need to examine 10 or 20 genomic regions (like single-nucleotide polymorphism (SNPs)). That is a tiny fraction of the human genome, which consists of three billion or so nucleotides.
When genotyping transgenic organisms, a single genomic region may be all that needs to be examined to determine the genotype. A single PCR assay is typically enough to genotype a transgenic mouse; the mouse is the mammalian model of choice for much of medical research today.
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