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Calorie-restricted weight loss restores ghrelin sensitivity

(HealthDay)—In a mouse model, calorie-restricted weight loss reverses the high-fat diet-induced ghrelin resistance that may contribute to rebound weight gain, according to research published online Jan. ...

Health created Jan 21, 2013 | popularity 5 / 5 (1) | comments 0

Scientists show protein linked to hunger also implicated in alcoholism

Researchers at The Scripps Research Institute have found new links between a protein that controls our urge to eat and brain cells involved in the development of alcoholism. The discovery points to new possibilities for designing ...

Psychology & Psychiatry created Sep 14, 2012 | popularity 5 / 5 (3) | comments 0 | with audio podcast

Lack of sleep is linked to obesity, new evidence shows

Can lack of sleep make you fat? A new paper which reviews the evidence from sleep restriction studies reveals that inadequate sleep is linked to obesity. The research, published in a special issue of the The American Journal of ...

Health created Apr 17, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

Appetite accomplice: Ghrelin receptor alters dopamine signaling

New research reveals a fascinating and unexpected molecular partnership within the brain neurons that regulate appetite. The study, published by Cell Press in the January 26 issue of the journal Neuron, resolv ...

Neuroscience created Jan 25, 2012 | popularity 5 / 5 (1) | comments 0 | with audio podcast

External stimuli control the hormonal regulation of our eating behavior

Max Planck researchers have proven something scientifically for the first time that laypeople have always known: the mere sight of delicious food stimulates the appetite. A study on healthy young men has documented ...

Health created Jan 19, 2012 | popularity 4.5 / 5 (2) | comments 2

Low ghrelin—reducing appetite at the cost of increased stress?

Ghrelin is a hormone released by the lining of the stomach that promotes feeding behavior. Decreasing ghrelin levels could potentially help combat obesity—in fact, a vaccine that lowers ghrelin levels in order to reduce ...

Psychology & Psychiatry created Sep 13, 2012 | popularity not rated yet | comments 0

Sleep duration affects hunger differently in men and women

A new study suggests that increasing the amount of sleep that adults get could lead to reduced food intake, but the hormonal process differs between men and women.

Health created Oct 31, 2012 | popularity not rated yet | comments 0

Saving carbs for dinnertime might help control weight

(HealthDay)—When it comes to eating pasta, bread and potatoes, timing could be everything.

Overweight and Obesity created Dec 13, 2012 | popularity 3 / 5 (2) | comments 0

Ghrelin increases willingness to pay for food

Research to be presented at the upcoming annual meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, suggests that ghrelin, ...

Other created Jul 12, 2011 | popularity not rated yet | comments 2

Ratio of appetite-regulating hormones marker of successful dieters

A pre-diet measurement of two hormones related to weight regulation can help predict which dieters will be more likely to maintain their weight loss and who will not, according to a new study. The results will be presented ...

Overweight and Obesity created Jun 25, 2012 | popularity not rated yet | comments 0

New imaging agent has an appetite for dangerous prostate tumors

Non-invasive imaging detects prostate cancer earlier than ever before, but can't accurately distinguish between malignant and benign disease. According to Lawson Health Research Institute's Drs. John Lewis and Len Luyt, a ...

Cancer created Dec 08, 2011 | popularity 5 / 5 (1) | comments 1

Feeding hormone ghrelin modulates ability of rewarding food to evoke dopamine release

New research findings to be presented at the upcoming annual meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, finds that ...

Medical research created Jul 12, 2011 | popularity not rated yet | comments 0

Ghrelin

Ghrelin is a 28 amino acid peptide and hormone that is produced mainly by P/D1 cells lining the fundus of the human stomach and epsilon cells of the pancreas that stimulates hunger. Ghrelin levels increase before meals and decrease after meals. It is considered the counterpart of the hormone leptin, produced by adipose tissue, which induces satiation when present at higher levels. In some bariatric procedures, the level of ghrelin is reduced in patients, thus causing satiation before it would normally occur.

Ghrelin is a potent stimulator of growth hormone from the anterior pituitary gland. The ghrelin receptor is a G protein-coupled receptor, known as the growth hormone secretagogue receptor. Ghrelin binds to the GHSR1a splice-variant of this receptor which is present in high density in the hypothalamus, pituitary as well as vagal afferent cell bodies and vagal afferent endings throughout the gastro-intestinal tract

Ghrelin plays a significant role in neurotrophy, particularly in the hippocampus, and is essential for cognitive adaptation to changing environments and the process of learning. Recently, ghrelin has been shown to activate the endothelial isoform of nitric oxide synthase in a pathway that depends on various kinases including Akt.

For more information about Ghrelin, read the full article at Wikipedia.
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