Poliovirus vaccine trial shows early promise for recurrent glioblastoma
An attack on glioblastoma brain tumor cells that uses a modified poliovirus is showing encouraging results in an early study to establish the proper dose level, researchers at Duke Cancer Institute report.
Cancer
May 21, 2013 |
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5-ALA fluorescence guides resection of recurrent glioblastoma multiforme
Neurosurgeons from UC San Francisco describe the use of 5-aminolevulinic acid (5-ALA) fluorescence in guiding resection of recurrent glioblastoma multiforme (GBM). Ingestion of 5-ALA by a patient before surgery leads to fluorescence ...
Cancer
Feb 19, 2013 |
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Study finds new targets for drugs to defeat aggressive brain tumor
University of Pittsburgh Cancer Institute (UPCI) researchers have identified over 125 genetic components in a chemotherapy-resistant, brain tumor-derived cell line, which could offer new hope for drug treatment to destroy ...
Cancer
Dec 14, 2012 |
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Metabolic protein launches sugar feast that nurtures brain tumors
Researchers at The University of Texas MD Anderson Cancer Center have tracked down a cancer-promoting protein's pathway into the cell nucleus and discovered how, once there, it fires up a glucose metabolism pathway on which ...
Cancer
Nov 26, 2012 |
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Metabolic protein wields phosphate group to activate cancer-promoting genes
A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson ...
Cancer
Aug 16, 2012 |
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DNA deletions promote cancer, collateral damage makes it vulnerable
Genomic deletions promote cancer by carving up or eliminating tumor-suppressor genes, but now scientists report in the journal Nature that the collateral damage they inflict on neighboring genes exposes cancer cells to vul ...
Cancer
Aug 15, 2012 |
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Better treatment for brain cancer revealed by new molecular insights
Nearly a third of adults with the most common type of brain cancer develop recurrent, invasive tumors after being treated with a drug called bevacizumab. The molecular underpinnings behind these detrimental effects have now ...
Cancer
Jul 09, 2012 |
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Brain cancer vaccine proves effective
A new brain cancer vaccine tailored to individual patients by using material from their own tumors has proven effective in a multicenter phase 2 clinical trial at extending their lives by several months or longer. The patients ...
Cancer
Apr 17, 2012 |
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Researchers find coupling of proteins promotes glioblastoma development
Two previously unassociated proteins known to be overly active in a variety of cancers bind together to ignite and sustain malignant brain tumors, a research team led by scientists at The University of Texas MD Anderson Cancer ...
Cancer
Oct 21, 2011 |
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Uncovering the spread of deadly cancer
For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers at Case Western Reserve University School of Medicine have imaged individual cancer cells and the routes ...
Cancer
Aug 26, 2011 |
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Small molecules shed light on cancer therapies
Patients suffering from an aggressive brain cancer will benefit from the results of a University of Illinois study that could advance the development of targeted gene therapies and improve prognosis.
Cancer
Aug 22, 2011 |
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Molecule Nutlin-3a activates a signal inducing cell death and senescence in primary brain tumors
Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, ...
Cancer
Apr 20, 2011 |
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