News tagged with glycolysis
Related topics: cancer cells
Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+. The free energy released in this process is used to form the high-energy compounds ATP (adenosine triphosphate) and NADH (reduced nicotinamide adenine dinucleotide).
Glycolysis is a definite sequence of ten reactions involving ten intermediate compounds (one of the steps involves two intermediates). The intermediates provide entry points to glycolysis. For example, most monosaccharides, such as fructose, glucose, and galactose, can be converted to one of these intermediates. The intermediates may also be directly useful. For example, the intermediate dihydroxyacetone phosphate (DHAP) is a source of the glycerol that combines with fatty acids to form fat.
It occurs, with variations, in nearly all organisms, both aerobic and anaerobic. The wide occurrence of glycolysis indicates that it is one of the most ancient known metabolic pathways.
The most common type of glycolysis is the Embden-Meyerhof-Parnas pathway (EMP pathway), which was first discovered by Gustav Embden, Otto Meyerhof and Jakub Karol Parnas. Glycolysis also refers to other pathways, such as the Entner–Doudoroff pathway and various heterofermentative and homofermentative pathways. However, the discussion here will be limited to the Embden-Meyerhof pathway.
The entire glycolysis pathway can be separated into two phases:
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
A protein known to regulate how cells process glucose also appears to be a tumor suppressor, adding to the potential that therapies directed at cellular metabolism may help suppress tumor growth. In their report in the Dec. ...
Cancer Dec 06, 2012 | 5 / 5 (1) | 0 |
(HealthDay)—For children undergoing routine anesthesia for medically indicated magnetic resonance imaging (MRI), the metabolic signature varies with use of sevoflurane and propofol, according to a study ...
Other Oct 26, 2012 | not rated yet | 0 |
Behaving something like ravenous monsters, tumors need plentiful supplies of cellular building blocks such as amino acids and nucleotides in order to keep growing at a rapid pace and survive under harsh conditions. ...
Cancer Aug 23, 2012 | 5 / 5 (1) | 0 |
Metabolic state of brain cancer stem cells significantly different than the cancer cells they create
The metabolic state of glioma stem cells, which give rise to deadly glioblastomas, is significantly different from that of the brain cancer cells to which they give birth, a factor which helps those stem cells avoid treatment ...
Cancer Sep 06, 2011 | not rated yet | 0 |
EU-funded researchers have made good progress in understanding how cancer cells can sometimes resist the effects of chemotherapy. This new knowledge will move forward the development of increasingly effective ...
Cancer Jul 14, 2011 | 5 / 5 (1) | 0 |
ETH Zurich researchers have found a new role for a well-known signalling molecule, Hif1: the molecule suppresses the burning of fat, which may possibly promote obesity in humans.
Medical research Feb 14, 2012 | 5 / 5 (1) | 1
The condition tuberous sclerosis, due to mutation in one of two tumor suppressor genes, TSC1 or TSC2, causes the growth of non-malignant tumors throughout the body and skin. These tumors can be unsightly and cause serious ...
Cancer Oct 21, 2011 | not rated yet | 0
University of Rochester Medical Center scientists have proposed a new reason why acute myeloid leukemia, one of the most aggressive cancers, is so difficult to cure: a subset of cells that drive the disease appear to have ...
Cancer Jan 17, 2013 | not rated yet | 0