Parkinson's & Movement disorders

A deep look into the progression of Parkinson's disease

Parkinson's disease is a complex neurodegenerative disorder that leads to the deterioration of specific types of neurons in the brain, resulting in a number of motor and non-motor symptoms. It is currently estimated that ...

Medical research

Palmitoylation, a new target for anti-cancer drugs

Peripheral membrane proteins temporarily bind to cell membranes, a necessary step for them to be able to fulfill their biological function. To do this, certain enzymes that catalyze their lipid modification come into action. ...

Oncology & Cancer

Pancreatic cancer blocked by disrupting cellular pH balance

Scientists at Sanford Burnham Prebys have found a new way to kill pancreatic cancer cells by disrupting their pH equilibrium. The study, published in Cancer Discovery, reports how depleting an ion transport protein lowers ...

Diabetes

New role for microtubules in diabetes

The failure of pancreatic beta cells to release appropriate amounts of insulin in response to rising blood glucose levels is a hallmark of type 2 diabetes.

Neuroscience

How manganese produces a parkinsonian syndrome

Using X-ray fluorescence at synchrotrons DESY and ESRF, researchers in the Centre d'Etudes Nucléaires de Bordeaux Gradignan (CNRS/Université de Bordeaux) have demonstrated the consequences of a mutation responsible for ...

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