Adhesion GPCRs are a group of G protein-coupled receptors associated with many bodily functions and diseases in humans. Scientists at Leipzig University have discovered a new receptor—which they have named "mayo"—and ...
Mar 15, 2024
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Roughly a third of all drugs approved by the U.S. Food and Drug Administration target a large family of biomolecules, known as G protein-coupled receptors (GPCRs), whose job is to trigger cellular responses to extracellular ...
Apr 27, 2022
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G protein-coupled receptors (GPCRs) are the largest family of membrane protein receptors. The proteins control how tissues and organs function. More than one-third of current drugs target these receptors.
Nov 5, 2020
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Duke University researchers have developed a synthetic molecule that selectively dampen the physiological rewards of cocaine in mice. It also may represent a new class of drugs that could be more specific with fewer side ...
May 28, 2020
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Mutations in a vital class of regulatory molecules are an underappreciated cause of cancer because they impair the function of "G" proteins, a versatile and vast family of signaling switches that underlie innumerable biological ...
A Purdue University-affiliated startup has created a platform aimed at treating relapse patients for cancers and other diseases by taking a holistic approach of not only seeking to impede the main cause but also to stop other ...
Jul 18, 2019
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Over one-third of all FDA-approved drugs act on a specific family of proteins: G-protein coupled receptors (GPCRs). Drugs to treat high blood pressure, asthma, cancer, diabetes and myriad other conditions target GPCRs throughout ...
May 20, 2019
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Leukemia is a deadly cancer in which rogue white blood cells roam the bloodstream, slowly killing the body that gave them life.
Feb 5, 2018
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Type 2 diabetes, a prolific killer, is on a steep ascent. According to the World Health Organization, the incidence of the condition has grown dramatically from 108 million cases in 1980 to well over 400 million today. The ...
May 17, 2017
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A team of scientists from Duke Medicine, the University of Michigan and Stanford University has determined the underlying architecture of a cellular signaling complex involved in the body's response to stimuli such as light ...
Jun 22, 2014
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