News tagged with heat shock proteins
Ganetespib shows potency against ALK-positive lung cancer and overcomes crizotinib resistance
A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK—positive non-small cell lung cancer.
Cancer
Mar 26, 2013 |
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Modified protein could become first effective treatment for vitiligo
Loyola University Chicago Stritch School of Medicine researchers have developed a genetically modified protein that dramatically reverses the skin disorder vitiligo in mice, and has similar effects on immune ...
Medical research
Feb 27, 2013 |
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Progressive exercise training may benefit diabetic neuropathy
(HealthDay)—In a rat model of diabetes, exercise is associated with decreased diabetes-associated neuropathic pain, which correlates with increased expression of heat shock protein 72 (Hsp72), according to a study published ...
Medical research
Feb 12, 2013 |
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New findings on heat shock proteins may shed light on variety of debilitating diseases
UCLA researchers, in a finding that runs counter to conventional wisdom, have discovered for the first time that a gene thought to express a protein in all cells that come under stress is instead expressed only in specific ...
Medical research
Jan 29, 2013 |
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Combination therapy using JAK2 and HSP90 inhibitors increased efficacy in myelofibrosis in vivo
Researchers have demonstrated that combination therapy with PU-H71 and ruxolitinib increases the durability and effectiveness of a treatment that had previously shown limited utility for patients with myelofibrosis.
Cancer
Dec 09, 2012 |
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Protein tug of war points toward better therapies for cardiovascular disease
Two proteins are in a tug of war that determines how much the body makes of superoxide, a highly reactive and potentially destructive product of oxygen that's dramatically elevated in cardiovascular disease, ...
Cardiology
Nov 15, 2012 |
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New drug to target and destroy tumor cells developed
A new drug created at the University of Minnesota may hold the answer to defeating pancreatic cancer, according to results published today in the prestigious journal Science Translational Medicine.
Cancer
Oct 18, 2012 |
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Impaired protein degradation causes muscle diseases
New insights into certain muscle diseases, the filaminopathies, are reported by an international research team led by Dr. Rudolf Andre Kley of the RUB's University Hospital Bergmannsheil in the journal Brain. The scientists from t ...
Medical research
Sep 25, 2012 |
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Breast cancer clinical trial tests combo of heat shock protein inhibitor and hormonal therapy
Pushed to the brink of survival, the hyper-driven cells of a cancerous tumor tap into an ancient system that has helped organisms cope with internal stresses and environmental challenges since life began. As an integral part ...
Cancer
May 22, 2012 |
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Treatment hope for Duchenne muscular dystrophy
An international team led by the University of Melbourne Australia, has found that increasing a specific protein in muscles could help treat Duchenne muscular dystrophy (DMD), a severe and progressive muscle wasting disease ...
Diseases, Conditions, Syndromes
Apr 04, 2012 |
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Researchers find potential solution to melanoma's resistance to vemurafenib
Researchers at Moffitt Cancer Center in Tampa, Fla., and colleagues in California have found that the XL888 inhibitor can prevent resistance to the chemotherapy drug vemurafenib, commonly used for treating patients with melanoma.
Cancer
Feb 28, 2012 |
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Researchers indentify a cell-permeable peptide that inhibits hepatitis C
Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a cell-permeable peptide that inhibits a hepatitis C virus protein and blocks viral replication, which can lead to liver cancer and cirrhosis.
Diseases, Conditions, Syndromes
Jan 31, 2012 |
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How protein networks stabilize muscle fibers: Same mechanism as for DNA
The same mechanism that stabilises the DNA in the cell nucleus is also important for the structure and function of vertebrate muscle cells. This has been established by RUB-researchers led by Prof. Dr. Wolfgang Linke (Institute ...
Genetics
Jan 23, 2012 |
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Pill some day may prevent serious foodborne illness, scientist says
Modified probiotics, the beneficial bacteria touted for their role in digestive health, could one day decrease the risk of Listeria infection in people with susceptible immune systems, according to Purdue University resear ...
Diseases, Conditions, Syndromes
Jan 09, 2012 |
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Towards more effective treatment for multiple myeloma
A new study from SUNY Downstate Medical Center in Brooklyn, New York, shows that MAL3-101, a recently developed inhibitor of the heat shock protein 70 (Hsp70), appears to have potent anti-tumor effects on multiple myeloma, ...
Cancer
Jan 09, 2012 |
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