News tagged with hematopoietic stem cells

Related topics: stem cells , blood cells , leukemia , bone marrow

Inhibiting CDK6 prevents leukemic relapse

Despite enormous progress in cancer therapy, many patients still relapse because their treatment addresses the symptoms of the disease rather than the cause, the so-called stem cells. Work in the group of ...

Jan 27, 2015
popularity 5 / 5 (1) | comments 0

Journey from stem cell to blood cell revealed

Researchers have discovered previously undetected steps in the process by which stem cells become blood cells, a process called haematopoiesis.  An international collaboration, including Winthrop Professor Wendy Erber, has ...

Sep 26, 2014
popularity 5 / 5 (2) | comments 0

Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are multipotent stem cells that give rise to all the blood cell types including myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid lineages (T-cells, B-cells, NK-cells). The definition of hematopoietic stem cells has undergone considerable revision in the last two decades. The hematopoietic tissue contains cells with long-term and short-term regeneration capacities and committed multipotent, oligopotent, and unipotent progenitors. Recently, long-term transplantation experiments point toward a clonal diversity model of hematopoietic stem cells. Here, the HSC compartment consists of a fixed number of different types of HSC, each with epigenetically preprogrammed behavior. This contradicts older models of HSC behavior, which postulated a single type of HSC that can be continuously molded into different subtypes of HSCs. HSCs constitute 1:10.000 of cells in myeloid tissue.

This text uses material from Wikipedia licensed under CC BY-SA