Diseases, Conditions, Syndromes

Understanding sickle cell disease

Sickle cell disease, which is a group of inherited red blood cell disorders, affects approximately 100,000 people in the U.S., according to the Centers for Disease Control and Prevention.

Medical research

Positive preliminary data on CRISPR treatment for blood diseases

A collaborative team of researchers, including Stephan Grupp, MD, Ph.D., Cell Therapy and Transplant Section Chief and Medical Director of the Cell and Gene Therapy Laboratory at Children's Hospital of Philadelphia (CHOP) ...

Diabetes

Tirzepatide noninferior, superior to semaglutide for T2DM

(HealthDay)—The dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, tirzepatide, is noninferior and superior to semaglutide for reducing glycated hemoglobin levels among patients ...

Medications

Safety, efficacy of vadadustat explored for CKD

(HealthDay)—Vadadustat met the noninferiority criteria for cardiovascular safety versus darbepoetin alfa among patients with dialysis-dependent chronic kidney disease (DD-CKD), but not those with non-DD-CKD (NDD-CKD), according ...

Diseases, Conditions, Syndromes

Toward a reliable oral treatment for sickle cell disease

For the millions of people worldwide who have sickle cell disease, there are only a few treatment options, which include risky bone marrow transplants, gene therapy or other treatments that address a subset of symptoms. Today, ...

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