Neuroscience

Histamine control of Tourette syndrome

(Medical Xpress)—Like narcolopsy, Tourettes syndrome is as much an enigma to the neuroscientists that study it, as it is to its sufferers. To say that we really understand nothing about how diseases like Tourettes actually ...

Diseases, Conditions, Syndromes

Scientists identify sensor underlying mechanical itch stimulus

Scientists at Scripps Research Institute have identified a protein in sensory nerves that works as a key detector of itch—specifically the "mechanical" itch stimulus of crawling insects, wool fibers, or other irritating ...

Medications

Histamine: an unexpected defender against heart and kidney damage

Chronic kidney disease and heart failure are critical medical problems worldwide, and are closely associated in a phenomenon known as "cardiorenal syndrome." The relationship between kidney dysfunction and heart dysfunction ...

Medical research

Tourette-like tics vanish in mice treated with histamine

Yale scientists produced increased grooming behavior in mice that may model tics in Tourette syndrome and discovered these behaviors vanish when histamine—a neurotransmitter most commonly associated with allergies—is ...

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Histamine

Histamine is an organic nitrogen compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. Histamine triggers the inflammatory response. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues.

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