News tagged with histones
Mapping the embryonic epigenome
A large, multi-institutional research team involved in the NIH Epigenome Roadmap Project has published a sweeping analysis in the current issue of the journal Cell of how genes are turned on and off to direct early human ...
Genetics
May 09, 2013 |
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Study shows potential new way to detect colorectal and other cancers
A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism explaining the previously ...
Cancer
Apr 25, 2013 |
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Novel therapeutic approaches to cure chronic HBV infection
Exciting new data presented today at the International Liver Congress 2013 include results from early in vitro and in vivo studies targeting covalently closed circular DNA (cccDNA), which may form the basis of a cure for ...
Diseases, Conditions, Syndromes
Apr 25, 2013 |
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Mechanism of mutant histone protein in childhood brain cancer revealed
(Medical Xpress)—Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. ...
Cancer
Apr 01, 2013 |
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Reprogramming cells to fight diabetes
For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, with limited success. The "reprogramming" of related alpha cells into beta cells ...
Medical research
Feb 22, 2013 |
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Protein that represses critical checkpoint protein for cellular growth helps drive tumor development
(Medical Xpress)—One of the hallmarks of cancer is unchecked cellular growth. Fortunately, our cells contain a number of tumor suppressor proteins, including the cell cycle regulator p21, to keep cell growth ...
Cancer
Feb 13, 2013 |
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Discovery offers unprecedented look at regulation of gene expression
(Medical Xpress)—A groundbreaking technique developed at the University of Virginia School of Medicine is allowing scientists to examine histone modifications of genetic loci – a process that regulates gene expression ...
Medical research
Jan 25, 2013 |
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Targeting histone deacetylases as a new strategy for graft versus host disease prevention
New research shows that the addition of the oral anti-cancer agent vorinostat to standard therapy given before, during, and after hematopoietic stem cell transplantation (HSCT) may safely reduce the incidence and severity ...
Medical research
Dec 09, 2012 |
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Scientists find Achilles' heel of cancer cells
Several substances inhibiting so-called HDAC enzymes have been studied in trials searching for new anti-cancer drugs in recent years. "Trials have shown that HDAC inhibitors are very effective in arresting growth of cultured ...
Cancer
Nov 05, 2012 |
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Addictive properties of drug abuse may hold key to an HIV cure
A Florida State University researcher is on a mission to explore the gene-controlling effects of addictive drugs in pursuit of new HIV treatments.
HIV & AIDS
Sep 21, 2012 |
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Epigenetic causes of prostate cancer
(Medical Xpress)—In about half of all prostate tumours, there are two genetic areas that are fused with one another. When this is not the case, the exact way cancer cells originate in prostate tumours was not clear until ...
Cancer
Sep 05, 2012 |
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Metabolic protein wields phosphate group to activate cancer-promoting genes
A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson ...
Cancer
Aug 16, 2012 |
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Researcher discovers epigenetic links in cell-fate decisions of adult stem cells
(Medical Xpress) -- The ability to control whether certain stem cells ultimately become bone cells holds great promise for regenerative medicine and potential therapies aimed at treating metabolic bone diseases.
Genetics
Jul 09, 2012 |
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Blocking DNA: HDAC inhibitor targets triple negative breast cancer
The histone de-acetylase (HDAC) inhibitor panobinostat is able to target and destroy triple negative breast cancer, reveals a new study published in BioMed Central's open access journal Breast Cancer Research. Researchers from T ...
Cancer
May 21, 2012 |
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Epigenetic changes in twins of dieting mothers increases risk of obesity and diabetes
(Medical Xpress) -- Women who fall pregnant while dieting are more likely to have a child that could become obese or diabetic in later life, new research suggests.
Genetics
Apr 01, 2012 |
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Histone
In biology, histones are highly alkaline proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. They are the chief protein components of chromatin, acting as spools around which DNA winds, and play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long (a length to width ratio of more than 10 million to one in human DNA). For example, each human cell has about 1.8 meters of DNA, but wound on the histones it has about 90 micrometers (0.09 mm) of chromatin, which, when duplicated and condensed during mitosis, result in about 120 micrometers of chromosomes.
For more information about Histone, read the full article at
Wikipedia.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
