Genetics

Change of temperature causes whole body reprogramming

Human beings, like most organisms, are constantly exposed to alternating colder or warmer temperatures. These environmental variations cause striking metabolic effects and require constant adaptations. While some of these ...

Medical research

Targeting TGF-β for treatment of osteogenesis imperfecta

A new study led by Baylor College of Medicine identifies an underlying mechanism of pathogenesis for osteogenesis imperfecta (OI) in human bone. The report, published in the Journal of Clinical Investigation, also shows the ...

Genetics

Pleistocene sediment DNA from Denisova Cave

Max Planck researchers have analyzed DNA from 728 sediment samples from Denisova Cave. Their study provides unprecedented detail about the occupation of the site by both archaic and modern humans over 300,000 years. The researchers ...

Immunology

Improving bone marrow transplants in mice to help fight disease

To study the immune system in human health and disease, scientists commonly use the genetic manipulation of mouse hematopoietic stem and progenitor cells (HSPCs) as a powerful model system. These studies have been extremely ...

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