Neuroscience
First patients dosed with 'gene silencing' drug for Huntington's disease
The first few patients have received doses of an experimental RNA-targeting drug for Huntington's disease, it was announced today.
Oct 19, 2015
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News tagged with huntingtin gene
Genetics
Genetic discovery may help determine effectiveness of Huntington's disease treatments
A new genetic discovery in the field of Huntington's disease (HD) could mean a more effective way in determining severity of this neurological disease when using specific treatments. This study may provide insight for treatments ...
Mar 2, 2015
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Neuroscience
Staying ahead of Huntington's disease
Huntington's disease is a devastating, incurable disorder that results from the death of certain neurons in the brain. Its symptoms show as progressive changes in behavior and movements.
Dec 11, 2013
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Neuroscience
Assay shown to be effective in measuring levels of mutant huntingtin protein
An assay designed to measure normal and abnormal forms of the huntingtin protein – the mutated form of which causes Huntington's disease (HD) – was successful in detecting levels of the mutant protein in a large multicenter ...
Aug 29, 2013
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Genetics
Novel test streamlines testing for Huntington Disease
A new test may help to streamline genetic testing for Huntington Disease (HD) by generating accurate results, avoiding unnecessary additional testing, and improving turnaround time. The test, which uses chimeric or triplet ...
Feb 13, 2013
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Genetics
New technique comprehensively generates three-dimensional maps of gene expression in the brain
A research team led by Yuko Okamura-Oho and Hideo Yokota of the RIKEN Advanced Science Institute, Wako, has developed a novel technique for three-dimensional (3D) mapping of gene expression patterns onto brain structures. ...
Jan 11, 2013
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Genetics
Genome-scale study identifies hundreds of potential drug targets for Huntington's disease
Scientists searching for ways to develop treatments for Huntington's disease (HD) just got a roadmap that could dramatically speed their discovery process. Researchers at the Buck Institute have used RNA interference (RNAi) ...
Nov 29, 2012
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Neuroscience
Enzyme inhibition protects against Huntington's disease damage in two animal models
Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended survival in two animal ...
Nov 29, 2012
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Diseases, Conditions, Syndromes
Immune cell migration is impeded in Huntington's disease
Huntington disease (HD) is an incurable neurodegenerative disease caused by a mutation in the huntingtin gene (htt). Though most of the symptoms of HD are neurological, the mutant HTT protein is expressed in non-neural cells ...
Nov 19, 2012
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Genetics
Scientists tackle Huntington's disease by targeting mutant gene
Huntington's disease is an inherited, neurodegenerative disorder that usually appears in mid-adult life and leads to uncoordinated body movements and cognitive decline. The disease is due to multiple repetitions of a deoxyribonucleic ...
Nov 6, 2012
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