Medications

How a novel drug pushes the HIV capsid to breaking point

Just over a year ago, the European Union and the US Food and Drug Administration approved a new anti-retroviral drug to treat human immunodeficiency virus (HIV) infections. Lenacapavir is the first drug available to patients ...

HIV & AIDS

Researchers pinpoint most likely source of HIV rebound infection

In findings that have implications for potential new HIV therapies, researchers from Texas Biomedical Research Institute (Texas Biomed) used genetic sequencing techniques on the nonhuman primate version of the virus to identify ...

Medical research

How does HIV get into the cell's center to kickstart infection?

UNSW medical researcher Dr. David Jacques and his team have discovered how the human immunodeficiency virus (HIV) breaches the cell nucleus to establish infection, a finding that has implications beyond HIV biology.

HIV & AIDS

Unlocking the mechanisms of HIV in preclinical research

Mayo Clinic researchers have unraveled the molecular mechanisms that affect which cells infected with human immunodeficiency virus (HIV) die and which survive, a discovery heralded as a step toward eliminating all HIV-infected ...

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Feline immunodeficiency virus

Feline immunodeficiency virus (FIV) is a lentivirus that affects domesticated housecats worldwide and is the causative agent of feline AIDS. Approximately 11% of cats worldwide, and about 2.5% of cats in the USA, are infected with FIV. FIV differs taxonomically from two other feline retroviruses, feline leukemia virus (FeLV) and feline foamy virus (FFV) and is more closely related to human immunodeficiency virus HIV. Within FIV, five subtypes have been identified based on amino acid sequence differences coding for the viral envelope. FIV is the only non-primate lentivirus to cause an AIDS-like syndrome, but FIV is not always a death sentence for cats, as they can live relatively healthily as carriers and transmitters of the disease for many years. A vaccine is available although its efficacy remains uncertain, and cats will test positive for FIV antibodies after vaccination.

FIV was first discovered in 1986 in a colony of cats that had a high prevalence of opportunistic infections and degenerative conditions, and has since been identified as an endemic disease in domestic cat populations worldwide .

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