Bioengineered rat kidneys developed by Massachusetts General Hospital (MGH) investigators successfully produced urine both in a laboratory apparatus and after being transplanted into living animals. In their report, receiving ...
Apr 14, 2013
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A 36-year-old man who had tracheal cancer has received a new lab-made windpipe seeded with his own stem cells in a procedure in Sweden they call the first successful attempt of its kind, officials said Thursday.
Jul 7, 2011
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The human cytomegalovirus, HCMV for short, lies dormant unnoticed in the body of most people for their entire lives. In immunocompromised individuals, however, the virus can cause life-threatening infections. It infects dendritic ...
Feb 27, 2024
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Academic researchers from King's College London have investigated the early effects of an immunosuppressant drug that could help clinicians with future personalized approaches for the treatment of psoriasis.
Feb 19, 2024
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In a preclinical breakthrough that could transform cell therapies for incurable diseases, researchers at Sinai Health and the University of Toronto have developed a technology that may one day eliminate the need for immunosuppressive ...
Nov 29, 2023
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Researchers from the University Medical Center Hamburg-Eppendorf and the University Hospital Bonn have demonstrated that certain derivatives of vitamin B2 can alleviate chronic kidney inflammation in mice. Their findings ...
Nov 21, 2023
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A team of surgeons in New York has performed the world's first transplant of an entire eye in a procedure widely hailed as a medical breakthrough, although it isn't yet known whether the man will ever see through the donated ...
Nov 9, 2023
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A large team of medical researchers affiliated with multiple institutions in the U.S. reports that genetically altering the genome of pigs can reduce the chance of rejection of their organs when transplanted into a primate.
One promising approach to treating type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections. However, one major ...
Sep 18, 2023
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A new study led by researchers at Harvard Medical School details the step-by-step cascade that allows bacteria to break through the brain's protective layers—the meninges—and cause brain infection, or meningitis, a highly ...
Mar 1, 2023
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Immunosuppressive drugs or immunosuppressive agents are drugs that inhibit or prevent activity of the immune system. They are used in immunosuppressive therapy to:
These drugs are not without side-effects and risks. Because the majority of them act non-selectively, the immune system is less able to resist infections and the spread of malignant cells. There are also other side-effects, such as hypertension, dyslipidemia, hyperglycemia, peptic ulcers, liver, and kidney injury. The immunosuppressive drugs also interact with other medicines and affect their metabolism and action. Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry.
Immunosuppressive drugs can be classified into five groups:
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