News tagged with insulin resistance

Related topics: type 2 diabetes · diabetes · metabolic syndrome · cell metabolism · fat cells

Genetic risk score IDs insulin resistance, change in IR

(HealthDay)—A genetic risk score based on 17 established insulin resistance (IR) variants and their effect sizes (weighted IR-GRS) is associated with IR at baseline and change in IR, but does not impact the effect of lifestyle ...

Nov 13, 2015
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Obesity and type 2 diabetes harm bone health

Obesity and Type 2 diabetes have been linked to several health issues, including an increased risk of bone fractures. In a new animal study, University of Missouri researchers examined how the development of obesity and insulin ...

Nov 17, 2015
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New diabetes risk mechanism identified

Researchers at Mayo Clinic have discovered an unexpected effect from a gene known to increase diabetes risk. They assumed that the specific allele in the gene TCF7L2 which increases the risk of type 2 diabetes, impairs insulin ...

Nov 12, 2015
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Insulin resistance

Insulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.

This text uses material from Wikipedia, licensed under CC BY-SA

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