News tagged with insulin resistance

Related topics: type 2 diabetes , diabetes , metabolic syndrome , cell metabolism , fat cells

Gut microbe battles obesity

(Medical Xpress)—Akkermansia muciniphila is one of the many microbes that live in our intestines. This bacterium, which feeds on the intestine's mucus lining, comprises between 3 and 5 percent of the gut microbes of hea ...

May 14, 2013
popularity 4.8 / 5 (11) | comments 0 | with audio podcast report

Insulin resistance

Insulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.

This text uses material from Wikipedia licensed under CC BY-SA