News tagged with insulin resistance

Scientists show how fatty diets cause diabetes

Newly diagnosed type 2 diabetics tend to have one thing in common: obesity. Exactly how diet and obesity trigger diabetes has long been the subject of intense scientific research. A new study led by Jamey ...

Medical research created Aug 14, 2011 | popularity 4.7 / 5 (14) | comments 13 | with audio podcast

Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: study

Researchers in the Faculty of Medicine & Dentistry at the University of Alberta have discovered that resveratrol, a powerful antioxidant found in common foods, prevents a syndrome in some offspring that could lead to later ...

Medical research created Sep 02, 2011 | popularity 4.6 / 5 (14) | comments 6 | with audio podcast

Diabetes may start in the intestines, research suggests

Scientists at Washington University School of Medicine in St. Louis have made a surprising discovery about the origin of diabetes. Their research suggests that problems controlling blood sugar — the hallmark ...

Diabetes created Feb 15, 2012 | popularity 4.1 / 5 (16) | comments 4 | with audio podcast

Study offers insight to how fructose causes obesity, metabolic syndrome

A group of scientists from across the world have come together in a just-published study that provides new insights into how fructose causes obesity and metabolic syndrome, more commonly known as diabetes.

Medical research created Feb 27, 2012 | popularity 4.9 / 5 (11) | comments 1 | with audio podcast

Gut microbe battles obesity

(Medical Xpress)—Akkermansia muciniphila is one of the many microbes that live in our intestines. This bacterium, which feeds on the intestine's mucus lining, comprises between 3 and 5 percent of the gut microbes of hea ...

Medical research created May 14, 2013 | popularity 4.8 / 5 (11) | comments 0 | with audio podcast report

Nutritional supplement may help prevent Alzheimer's, research suggests

(Medical Xpress)—A nutritional supplement available over-the-counter may offer protection from Alzheimer's disease, a study by the University of Virginia and Northwestern University suggests.

Alzheimer's disease & dementia created Jan 10, 2013 | popularity 4.2 / 5 (11) | comments 0 | with audio podcast

Specific toxic byproduct of heat-processed food may lead to increased body weight and diabetes

Researchers at Mount Sinai School of Medicine have identified a common compound in the modern diet that could play a major role in the development of abdominal obesity, insulin resistance, and type 2 diabetes. The findings ...

Medical research created Aug 20, 2012 | popularity 5 / 5 (8) | comments 3 | with audio podcast

Villain stomach bug may have a sweet side: Researchers reveal how 'bad' gut bacteria may help control diabetes

A stomach bacterium believed to cause health problems such as gastritis, ulcers, and gastric cancer may play a dual role by balancing the stomach's ecosystem and controlling body weight and glucose tolerance, according to ...

Medical research created Feb 08, 2013 | popularity 5 / 5 (8) | comments 0 | with audio podcast

Discovery of new hormone opens doors to new type 2 diabetes treatments

Harvard School of Public Health (HSPH) researchers have discovered that a particular type of protein (hormone) found in fat cells helps regulate how glucose (blood sugar) is controlled and metabolized (used for energy) in ...

Diabetes created May 07, 2013 | popularity 4.6 / 5 (8) | comments 1 | with audio podcast

Research proposes common link between autism, diabetes

A review of the genetic and biochemical abnormalities associated with autism reveals a possible link between the widely diagnosed neurological disorder and Type 2 diabetes, another medical disorder on the rise in recent decades.

Medical research created Oct 19, 2011 | popularity 4.4 / 5 (8) | comments 3 | with audio podcast

New study explains duality of longevity drug rapamycin

A Penn- and MIT-led team explained how rapamycin, a drug that extends mouse lifespan, also causes insulin resistance. The researchers showed in an animal model that they could, in principle, separate the effects, which depend ...

Medical research created Mar 29, 2012 | popularity 4.6 / 5 (7) | comments 1 | with audio podcast

Scientists identify key mechanism involved in Type 2 diabetes

Scientists at the Gladstone Institutes have discovered a key protein that regulates insulin resistance—the diminished ability of cells to respond to the action of insulin and which sets the stage for the development ...

Diabetes created Mar 28, 2012 | popularity 5 / 5 (6) | comments 0 | with audio podcast

Protective gene in fat cells may lead to therapeutic for Type 2 diabetes

In a finding that may challenge popular notions of body fat and health, researchers at Beth Israel Deaconess Medical Center (BIDMC) have shown how fat cells can protect the body against diabetes. The results may lead to a ...

Medical research created Apr 01, 2012 | popularity 4.8 / 5 (6) | comments 0 | with audio podcast

Saturated fatty acids lead to mitochondrial dysfunction and insulin resistance

Excessive levels of certain saturated fatty acids cause mitochondria to fragment, leading to insulin resistance in skeletal muscle, a precursor of type 2 diabetes, according to a paper in the January issue of the journal ...

Medical research created Jan 20, 2012 | popularity 4.2 / 5 (6) | comments 8

Scientists find molecular link to obesity and insulin resistance in mice

Flipping a newly discovered molecular switch in white fat cells enabled mice to eat a high-calorie diet without becoming obese or developing the inflammation that causes insulin resistance, report scientists ...

Medical research created Sep 27, 2012 | popularity 5 / 5 (5) | comments 0 | with audio podcast

Insulin resistance

Insulin resistance (IR) is the condition in which normal amounts of insulin are inadequate to produce a normal insulin response from fat, muscle and liver cells. Insulin resistance in fat cells reduces the effects of insulin and results in elevated hydrolysis of stored triglycerides in the absence of measures which either increase insulin sensitivity or which provide additional insulin. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Insulin resistance in muscle cells reduces glucose uptake (and so local storage of glucose as glycogen), whereas insulin resistance in liver cells results in impaired glycogen synthesis and a failure to suppress glucose production. Elevated blood fatty acid levels (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are believed to be the origin of metabolic syndrome and type 2 diabetes, including its complications.

For more information about Insulin resistance, read the full article at Wikipedia.
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