Next-generation drugs against the sometimes fatal disease amebiasis could result from a RIKEN researcher's new strategy targeting a source of iron that an infectious protozoan parasite needs to proliferate.
May 9, 2022
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A multi-year study of the role of E. coli gut bacteria in Crohn's disease finds that intestinal inflammation liberates chemicals that nourish the bacteria's growth and promotes its ability to cause inflammation.
Apr 27, 2022
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In patients with familial adenomatous polyposis, a genetic disease predisposing to colon cancer, mutations of the APC gene induce the formation of intestinal polyps, but also reduce immune system activity. In a new study, ...
Apr 14, 2022
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According to the World Health Organization, more than 1 billion people are infected with parasitic helminths worldwide, but the prevention and treatment of helminth infection remain challenging. Research led by the University ...
Apr 13, 2022
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Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea. Such pathogens pose significant ...
Apr 8, 2022
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Chimeric antigen receptor (CAR) T cells can be remarkably effective in treating leukemias and lymphomas, but there are no successful immunotherapies for neuroendocrine tumors (NETs) and gastrointestinal cancers (GICs) yet. ...
Mar 24, 2022
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Investigators at the Brigham and the Broad Institute have created specialized, tissue-like structures in the laboratory to model barrier tissues, such as the intestines, to identify new targets for treatment. Barrier tissues ...
Mar 22, 2022
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Individual Candida albicans yeast strains in the human gut are as different from each other as the humans that carry them, and some C. albicans strains may damage the gut of patients with inflammatory bowel disease (IBD), ...
Mar 16, 2022
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Intestinal cells can change specializations during their lives. The BMP signaling pathway—an important communication mechanism between cells—appears to be the driver of these changes. That is what scientists from the ...
Mar 1, 2022
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During the past ten years, scientists who study how the human body develops and functions on the most basic level have enjoyed a renaissance of sorts, thanks to structures called organoids—tiny 3D models of organs developed ...
Feb 16, 2022
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