News tagged with irinotecan
Related topics: chemotherapy
Irinotecan
Irinotecan (Camptosar, Pfizer; Campto, Yakult Honsha) is a drug used for the treatment of cancer.
Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin.
Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan.
Irinotecan received accelerated approval by the U.S. Food and Drug Administration (FDA) in 1996 and full approval in 1998. During development, it was known as CPT-11.
This text uses material from Wikipedia and is available under the GNU Free Documentation License.
Geriatric factors can foretell tolerances to chemotherapy
(HealthDay)—For elderly patients with metastatic colorectal cancer (mCRC), scores on the Mini-Mental State Examination (MMSE) and Instrumental Activities of Daily Living (IADL) were predictive of severe ...
Cancer
Mar 14, 2013 |
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Pharmacy researcher finds most popular weight-loss drug strongly alters other drug therapies
A University of Rhode Island researcher has discovered that the weight-loss drug orlistat, known by the brand names Xenical and Alli, inhibits a key enzyme that may lead to "severe toxicity of internal organs such as the ...
Medications
Dec 10, 2012 |
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Trial offers new hope to children and adults with muscle cancer
A Cancer Research UK funded trial will offer new treatments for children and adults with a form of muscle cancer called rhabdomyosarcoma that has returned or does not respond to current treatments. ...
Cancer
Oct 22, 2012 |
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Drug trial offers hope to patients with advanced colorectal cancer
A new drug treatment could offer hope to patients with advanced colorectal cancer who were intolerant of or did not respond to standard treatments, according to an article published in the Lancet Oncology.
Cancer
Aug 27, 2012 |
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Zaltrap approved for advanced colorectal cancer
(HealthDay) -- Zaltrap (ziv-afilbercept) has been approved by the U.S. Food and Drug Administration in combination with a FOLFIRI chemotherapy regimen for adults with advanced metastatic (spreading) colorectal cancer, the ...
Medications
Aug 04, 2012 |
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Dose-escalated cetuximab tolerated in colorectal cancer
(HealthDay) -- For patients with irinotecan-refractory metastatic colorectal cancer (CRC), dose escalation of cetuximab is well tolerated and may improve response and disease control rates, but patients experience ...
Cancer
Jul 05, 2012 |
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ASCO: Continuing avastin with 2nd-line chemo ups survival
(HealthDay) -- Continuing use of bevacizumab (Avastin) in combination with second-line chemotherapy improves overall survival (OS) and progression-free survival (PFS) in patients with metastatic colorectal ...
Cancer
Jun 05, 2012 |
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How chemotherapy becomes more effective
Researchers from the University of Zurich have found a cellular brake that protects cancer cells from chemotherapy -- and they demonstrate which medication can be used to render it inoperative. Their study published in the ...
Cancer
Mar 05, 2012 |
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