News tagged with journal of clinical investigation

Balancing T cell populations

Depending on the signals received, naïve T cells are able to differentiate into mature T cell populations, which play different roles in the immune system. For example, regulatory T cells (Tregs) are important for tamping ...

Nov 25, 2013
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Insights into type 2B von Willebrand disease

In response to blood vessel damage, von Willebrand factor (vWF) binds to the exposed extra cellular matrix, recruits platelets to the site of injury, and activates platelets, which promotes thrombis formation. Patients with ...

Nov 25, 2013
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Liver tropism is key for B cell deletion immunotherapy

Antibodies against the B cell surface protein CD20 have been used successfully to treat B cell-mediated autoimmune diseases and lymphomas. Antibody binding receptors, called Fc receptors, on other immune cells bind anti-CD20 ...

Nov 01, 2013
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Itch maintains regulatory T cell stability

Regulatory T cells (Tregs) function to suppress immune responses of other cells, and their dysfunction has been associated with development of immune disorders. Recent studies suggest that Tregs maintain plasticity even after ...

Oct 26, 2013
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