News tagged with journal of clinical investigation

Liver tropism is key for B cell deletion immunotherapy

Antibodies against the B cell surface protein CD20 have been used successfully to treat B cell-mediated autoimmune diseases and lymphomas. Antibody binding receptors, called Fc receptors, on other immune cells bind anti-CD20 ...

Nov 01, 2013
popularity not rated yet | comments 0

Itch maintains regulatory T cell stability

Regulatory T cells (Tregs) function to suppress immune responses of other cells, and their dysfunction has been associated with development of immune disorders. Recent studies suggest that Tregs maintain plasticity even after ...

Oct 26, 2013
popularity 5 / 5 (4) | comments 0

A link between type 2 diabetes and mitochondrial function

Type 2 diabetes is a chronic condition that is characterized by resistance to or insufficient production of insulin, a hormone that controls sugar movement into cells. In certain tissues, insulin resistance has been associated ...

Oct 01, 2013
popularity 5 / 5 (1) | comments 0

Important wound-healing process discovered

Scientists at The Scripps Research Institute (TSRI) have discovered an important process by which special immune cells in the skin help heal wounds. They found that these skin-resident immune cells function as "first responders" ...

Sep 26, 2013
popularity 5 / 5 (2) | comments 0 | with audio podcast

A link between zinc transport and diabetes

Individuals with a mutation in the gene encoding a zinc transporter, SLC30A8 have an elevated risk of developing type 2 diabetes. Insulin granules that are released from pancreatic β cells contain high levels of zinc; however, ...

Sep 24, 2013
popularity 5 / 5 (1) | comments 0