News tagged with journal of clinical investigation
Related topics: protein , mouse model , cells , cancer cells , immune system
Study may lead to new strategies against sepsis
Scientists at the Center for Translational Medicine at the Temple University School of Medicine are inching closer to solving a long-standing mystery in sepsis, a complex and often life-threatening condition that affects ...
Medical research
Jan 25, 2013 |
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Potential new treatment for gastrointestinal cancers discovered
(Medical Xpress)—Researchers have identified a complex of proteins that promotes the growth of some types of colon and gastric cancers, and shown that medications that block the function of this complex ...
Cancer
Jan 17, 2013 |
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Could probiotics help HIV patients?
Antiretroviral (ARV) drugs are the first line therapy for patients with HIV; however, ARV-treated, HIV-infected individuals still have a higher mortality rate than uninfected individuals. During the course of infection, HIV ...
HIV & AIDS
Jan 16, 2013 |
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Hepatitis B virus promotes oncogenesis through microRNA modulation
Viruses prompt oncogenic transformation by genetically altering infected cells. Several recent studies have demonstrated that viruses alter the expression of microRNAs, non-coding RNA molecules that can block the expression ...
Diseases, Conditions, Syndromes
Jan 16, 2013 |
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Body's ibuprofen, SPARC, reduces inflammation and thus bladder cancer development and metastasis
Cancer researchers are increasingly aware that in addition to genetic mutations in a cancer itself, characteristics of the surrounding tissue can promote or suppress tumor growth. One of these important tissue characteristics ...
Cancer
Jan 16, 2013 |
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A new treatment for kidney disease-associated heart failure?
Chronic kidney disease (CKD) patients frequently suffer from mineral bone disorder, which causes vascular calcification and, eventually, chronic heart failure. Similar to patients with CKD, mice with low levels of the protein ...
Diseases, Conditions, Syndromes
Jan 09, 2013 |
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Fusion gene contributes to glioblastoma progression
Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice.
Cancer
Jan 09, 2013 |
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Small peptide ameliorates autoimmune skin blistering disease in mice
Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive ...
Immunology
Jan 09, 2013 |
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Shifting the balance between good fat and bad fat
In many cases, obesity is caused by more than just overeating and a lack of exercise. Something in the body goes haywire, causing it to store more fat and burn less energy. But what is it? Researchers at ...
Medical research
Jan 04, 2013 |
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Bacterial imbalance contributes to intestinal inflammation and carcinogenesis
Instability in the composition of gut bacterial communities (dysbiosis) has been linked to common human intestinal disorders, including inflammatory bowel disease and colorectal cancer; however, it is unclear if dysbiosis ...
Inflammatory disorders
Jan 02, 2013 |
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Identifying the molecular causes of vision loss in demyelinating disease
Demyelinating diseases, such as multiple sclerosis (MS), are frequently associated with the progressive loss of vision. The retinal nerve damage is thought to be caused by immune system-mediated inflammation; however, other ...
Ophthalmology
Jan 02, 2013 |
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Team finds molecule that polices TB lung infection, could lead to vaccine
The presence of a certain molecule allows the immune system to effectively police tuberculosis (TB) of the lungs and prevent it from turning into an active and deadly infection, according to a new study led by researchers ...
Diseases, Conditions, Syndromes
Jan 02, 2013 |
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New insights into how immune system fights atherosclerosis
A study led by Columbia University Medical Center (CUMC) researchers has found that an important branch of the immune system, in reaction to the development of atherosclerotic lesions, mounts a surprisingly robust anti-inflammatory ...
Immunology
Dec 21, 2012 |
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Ironing out the link between H. pylori infection and gastric cancer
H. pylori frequently causes gastric ulcers and is also one of the greatest risk factors for gastric cancer. H. pylori infection is also associated with another gastric cancer risk factor, iron deficiency.
Cancer
Dec 21, 2012 |
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The X factor in liver metabolism
After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway ...
Medical research
Dec 21, 2012 |
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