News tagged with journal of clinical investigation
Related topics: protein , mouse model , cells , cancer cells , immune system
A code of silence in acute myeloid leukemia
The development of acute myeloid leukemia (AML) is associated with a variety of genetic changes. Some of these alterations are epigenetic, wherein the sequence of the genes is unchanged, but chemical modifications to the ...
Cancer
Nov 19, 2012 |
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Immune cell migration is impeded in Huntington's disease
Huntington disease (HD) is an incurable neurodegenerative disease caused by a mutation in the huntingtin gene (htt). Though most of the symptoms of HD are neurological, the mutant HTT protein is expressed in non-neural cells ...
Diseases, Conditions, Syndromes
Nov 19, 2012 |
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Can the addition of radiolabeled treatments improve outcomes in advanced metastatic disease?
Radiolabeled agents are powerful tools for targeting and killing cancer cells and may help improve outcomes and lengthen survival times of patients with advanced disease that has spread beyond the initial ...
Cancer
Nov 13, 2012 |
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Home field advantage: Intravaginal immunization may help protect against infection
Sexually-transmitted diseases (STDs) enter the body through the mucosal epithelial cells and the ability to direct pathogen-clearing T-cells to points of infection may be the critical element in developing successful vaccines ...
Immunology
Nov 12, 2012 |
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HIV-1 vaccine development: Pinning down a moving target
HIV-1 is a genetically diverse collection of viruses, making it a moving target in vaccine development.
HIV & AIDS
Nov 12, 2012 |
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Study justifies L-DOPA therapy for Angelman syndrome
Last year a clinical trial of L-DOPA—a mainstay of Parkinson's disease therapy—was launched for Angelman syndrome, a rare intellectual disorder that shares similar motor symptoms such as tremors and difficulty ...
Medical research
Nov 12, 2012 |
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Study suggests caution and further studies on drugs used to treat macular degeneration
Millions of people with "wet" macular degeneration are prescribed a class of medication known as anti-VEGF drugs. But now scientists at The Scripps Research Institute (TSRI) have found that a drastic reduction of VEGF activity ...
Cancer
Oct 25, 2012 |
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Timing is everything when it comes to weight loss, research shows
Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss – why the weight inevitably ...
Overweight and Obesity
Oct 24, 2012 |
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Research findings breathe new life into lung disease
It turns out the muscle cells on the outside of blood vessels have been wrongly accused for instigating lung disease. New research shows that while these muscle cells are responsible for constricting or dilating the blood ...
Medical research
Oct 24, 2012 |
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Study identifies biological mechanism that plays key role in early-onset dementia
Using animal models, scientists at the Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD)—a form of early-onset dementia that is similar to Alzheimer's disease. ...
Neuroscience
Oct 08, 2012 |
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Endotrophin links obesity to breast cancer progression
Fat cells (adipocytes) surround breast tumors and contribute to tumor growth by expressing factors that aid oncogenesis. Col6 is a protein that is highly expressed in adipocytes and its expression is further increased in ...
Cancer
Oct 08, 2012 |
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Bitter taste receptors regulate the upper respiratory defense system, research shows
A new study from a team of researchers at the Perelman School of Medicine at the University of Pennsylvania, the Monell Chemical Senses Center, and the Philadelphia VA Medical Center, reveals that a person's ability to taste ...
Medical research
Oct 08, 2012 |
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Putting a 'HEX' on muscle regeneration
A complex genetic regulatory network mediates the regeneration of adult skeletal muscles. In this issue of the Journal of Clinical Investigation, researchers at the State University of New York Downstate Medical Center in Bro ...
Medical research
Oct 01, 2012 |
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NIH launches trial for rare degenerative muscle disease treatment
Researchers have launched a clinical trial to evaluate the drug candidate DEX-M74 as a treatment for a rare degenerative muscle disease, hereditary inclusion body myopathy (HIBM). National Institutes of Health scientists ...
Medical research
Sep 24, 2012 |
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Small proteins in the cornea protect against bacterial infection
When it comes to germ-busting power, the eyes have it, according to a discovery by University of California, Berkeley, researchers that could lead to new, inexpensive antimicrobial drugs.
Medical research
Sep 24, 2012 |
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