News tagged with journal of clinical investigation
Related topics: protein , mouse model , cells , cancer cells , immune system
New class of proteins allows breast cancer cells to evade tyrosine kinase inhibitors
Aberrant regulation of cell growth pathways is required for normal cells to become cancerous, and in many types of cancer, cell growth is driven by a group of enzymes known as receptor tyrosine kinases (RTKs). The RTK epidermal ...
Cancer
Aug 13, 2012 |
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Researchers discover blood biomarker for Lou Gehrig's disease, could lead to new treatments
Researchers from Brigham and Women's Hospital (BWH) are the first to discover that changes in monocytes (a type of white blood cell) are a biomarker for amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. This finding ...
Medical research
Aug 06, 2012 |
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Lifting malaria's deadly veil: mystery solved in quest for vaccine
(Medical Xpress) -- Researchers at the Burnet Institute have made a major breakthrough in the quest for a vaccine against malaria, which causes up to one million deaths each year.
Medical research
Aug 06, 2012 |
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Scientists first to see trafficking of immune cells in beating heart
Blood flow to the heart often is interrupted during a heart attack or cardiac surgery. But when blood flow resumes, the heart may still falter. That's because collateral damage can occur as blood re-enters ...
Medical research
Jul 11, 2012 |
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Cell differentiation as a novel strategy for the treatment of an aggressive type of skin cancer
Skin squamous cell carcinoma (SCC) is a subtype of very aggressive skin cancers that usually develops in sunexposed body regions, but can also affect a large number of organs such as the bladder, esophagus, lungs etc. However, ...
Cancer
Jul 09, 2012 |
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Researchers report success in treating autism spectrum disorder
Using a mouse model of autism, researchers at the University of Cincinnati (UC) and Cincinnati Children's Hospital Medical Center have successfully treated an autism spectrum disorder characterized by severe cognitive impairment.
Autism spectrum disorders
Jul 02, 2012 |
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Surprising culprit behind chemo resistance in rare cancer
Researchers at Washington University School of Medicine in St. Louis have shown how an aggressive form of multiple myeloma resists chemotherapy.
Cancer
Jul 02, 2012 |
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Even after Lyme disease is gone, its remains may perpetuate inflammation
(Medical Xpress) -- Non-infectious proteins of the species of bacteria that causes Lyme disease can remain in the body for a long time after antibiotic therapy, and are capable of causing an inflammatory immune ...
Inflammatory disorders
Jun 26, 2012 |
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The right combination: Overcoming drug resistance in cancer
Overactive epidermal growth factor receptor (EGFR) signaling has been linked to the development of cancer. Several drug therapies have been developed to treat these EGFR-associated cancers; however, many patients have developed ...
Cancer
Jun 01, 2012 |
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New drug strategy attacks resistant leukemia and lymphoma
Scientists at the Dana-Farber/Children's Hospital Cancer Center have developed an anti-cancer peptide that overcomes the stubborn resistance to chemotherapy and radiation often encountered in certain blood cancers when the ...
Cancer
May 29, 2012 |
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A boost in microRNA may protect against sepsis and other inflammatory diseases
Acute inflammatory diseases, such as sepsis, as well as chronic inflammatory diseases like diabetes and arthritis, develop as a result of sustained inflammation of the blood vessel wall. Researchers at Brigham and Women's ...
Inflammatory disorders
May 24, 2012 |
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Scientists discover marker to identify, attack breast cancer stem cells
Breast cancer stem cells wear a cell surface protein that is part nametag and part bull's eye, identifying them as potent tumor-generating cells and flagging their vulnerability to a drug, researchers at The University of ...
Cancer
May 16, 2012 |
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Protein inhibitor points to potential medical treatments for skull and skin birth defects
Researchers at Mount Sinai School of Medicine in New York have found new clues in the pathogenesis of skull and skin birth defects associated with a rare genetic disorder, Beare-Stevenson cutis gyrata syndrome (BSS). Using ...
Pediatrics
May 15, 2012 |
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Mystery gene reveals new mechanism for anxiety disorders
A novel mechanism for anxiety behaviors, including a previously unrecognized inhibitory brain signal, may inspire new strategies for treating psychiatric disorders, University of Chicago researchers report.
Genetics
May 15, 2012 |
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Exhaustion renders immune cells less effective in cancer treatment
Rather than stimulating immune cells to more effectively battle cancerous tumors, treatment with the protein interleukin-12 (IL-12) has the opposite effect, driving these intracellular fighters to exhaustion, a Mayo Clinic ...
Immunology
May 09, 2012 |
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