The Journal of Experimental Medicine is a peer-reviewed academic journal that publishes research papers and commentaries in the biomedical area. Topics covered include immunology, inflammation, infectious disease, hematopoiesis, cancer, stem cells and vascular biology. The journal has a history of predominantly publishing basic research, although studies in human subjects form an increasing proportion of papers published (around 10% in 2004).

JEM was founded in 1896, which makes it among the longest established of scientific journals. Initially published at the Johns Hopkins University, it was taken over in 1905 by the Rockefeller University Press, the current publishers, and is published on a not-for-profit basis. There is no single Editor-in-Chief, with eleven academic Editors and a hundred strong Advisory Board.

JEM is published monthly. An online archive of articles back to 1896 is available in text and PDF formats (material from 1996 and earlier is only available in PDF). Material over 6 months old is freely accessible, and access to all papers is also provided free of charge to developing countries. All of the content of JEM is also deposited in PubMed Central where it is available to the public 6 months after publication. Copyright to articles remains with the authors and third parties may re-use JEM content under the terms of a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license described at http://creativecommons.org/licenses/by-nc-sa/3.0/.

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