Diabetes

Metal binding important for metformin action

(HealthDay) -- The ability of metformin to bind mitochondrial copper may be essential to its mechanism of action, according to a study published online April 9 in Diabetes.

Oncology & Cancer

Why some tumors withstand treatment

New cancer drugs allow doctors to tailor treatment based on the genetic profile of a patient's tumor. However, these drugs don't work at all in some patients, and they lose their effectiveness in others.

Medications

Locking leukemia's cellular escape hatch

Leukemia starts in cells that would normally develop into different types of blood cells. About 61,000 people in the U.S. are diagnosed each year, and depending on the type of leukemia and the age of the patient, five-year ...

Medications

Rewiring the biology of leukemia cells to reverse drug resistance

Researchers from Barts Cancer Institute at Queen Mary University of London have identified a way to reverse resistance to a group of cancer drugs, known as kinase inhibitors, in leukemia cells. By rewiring the inner workings ...

Oncology & Cancer

Researchers develop an algorithm to improve cancer treatment

UVA Health Cancer Center researchers have developed an algorithm that will improve cancer care by quickly and easily identifying patients who will benefit from powerful cancer drugs called kinase inhibitors. The algorithm ...

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