Targeting a specific protein that is often overexpressed in prostate cancer can help prevent or delay the disease from spreading to other parts of the body, according to a study led by Cedars-Sinai Cancer investigators.
Feb 25, 2022
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93
Interleukin-12 (IL-12), a potent inducer of cell-mediated immunity, can stimulate the anti-tumor effector functions of the activated T and NK cells for solid tumors rejection. However, clinical administration of IL-12 has ...
Jan 10, 2022
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39
ALK is a receptor tyrosine kinase that regulates important functions in the central nervous system. Scientists at St. Jude Children's Research Hospital have used leading-edge structural biology techniques to reveal in more ...
Nov 24, 2021
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83
A collaboration among scientists from UCLA and other universities in California, Delaware and Germany, as well as a German pharmaceutical company, has singled out a compound that shows promise for treating SARS-CoV-2, the ...
Mar 25, 2021
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118
There could be an intervention on the horizon to help prevent heart damage caused by the common chemotherapy drug doxorubicin, new research suggests.
Jan 25, 2021
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The year 2021 marks the 100th anniversary of a fundamental discovery that's taught in every biochemistry textbook. In 1921, German physician Otto Warburg observed that cancer cells harvest energy from glucose sugar in a strangely ...
Jan 22, 2021
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Vanderbilt researchers have discovered a unique pathway that initiates islet β cell inflammation—a hallmark of type 2 diabetes—putting them a step closer to developing targeted therapeutics for the disease that affects ...
Jan 13, 2021
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25
In a new study, Johns Hopkins Medicine researchers have shown how an enzyme can activate and engage a "trash and recycling system" in heart cells to help patients better recover from a heart attack. The researchers say in ...
Dec 23, 2020
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174
For scientists hoping to harness a powerful new technique for demolishing cellular enzymes known as kinases, the choices can be a bit overwhelming. Some 514 different protein kinases toil in human cells, representing 2.5% ...
Dec 3, 2020
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31
Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete. It could provide a promising new target to develop drugs for boosting insulin production in people with Type 2 ...
Nov 13, 2020
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