News tagged with kinases
Enzyme that flips switch on cells' sugar cravings could be anti-cancer target
Cancer cells tend to take up more glucose than healthy cells, and researchers are increasingly interested in exploiting this tendency with drugs that target cancer cells' altered metabolism.
Cancer
Dec 22, 2011 |
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Drugs used to overcome cancer may also combat antibiotic resistance: researchers
Drugs used to overcome cancer may also combat antibiotic resistance, finds a new study led by Gerry Wright, scientific director of the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University.
Medical research
Dec 22, 2011 |
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Novel experimental agent is highly active in CLL patients, interim study shows
An interim analysis of a phase Ib/II clinical trial indicates that a novel experimental agent for chronic lymphocytic leukemia (CLL) is highly active and well tolerated in patients who have relapsed and are resistant to other ...
Cancer
Dec 11, 2011 |
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Lipid-modifying enzyme: New target for pan-viral therapeutics
Three different disease-causing viruses -- poliovirus, coxsackievirus, and hepatitis C -- rely on their unwilling host for the membrane platforms enriched in a specific lipid, phosphatidylinositol 4 phosphate (PI4P) on which ...
Medical research
Dec 07, 2011 |
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Novel monoclonal antibody offers potential treatment for tumors resistant to VEGF therapy
Despite the widespread use of current antiangiogenic cancer therapies, many tumors escape this blockade, which is designed to shut down growth of new blood vessels that feed tumors and spread cancer cells. Now, a study reported ...
Cancer
Nov 13, 2011 |
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Study finds clue to birth defects in babies of mothers with diabetes
In a paper published today in Diabetologia, a team at Joslin Diabetes Center, headed by Mary R. Loeken, PhD, has identified the enzyme AMP kinase (AMPK) as key to the molecular mechanism that significantly increases the ri ...
Diseases, Conditions, Syndromes
Oct 17, 2011 |
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Combination therapies for drug-resistant cancers
Some cancers can be effectively treated with drugs inhibiting proteins known as receptor tyrosine kinases, but not those cancers caused by mutations in the KRAS gene. A team of researchers led by Jeffrey Engelman, at Massachusetts ...
Cancer
Oct 10, 2011 |
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Separating a cancer prevention drug from heart disease risk
Several clinical studies have shown that taking the anti-inflammatory drug celecoxib can reduce the risk of developing polyps that lead to colon cancers, at the cost of increasing the risk of heart disease. But what if this ...
Cancer
Sep 13, 2011 |
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Enzyme might be target for treating smoking, alcoholism at same time
An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, ...
Medical research
Sep 12, 2011 |
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Leukemia drug reverses tamoxifen-resistance in breast cancer cells
Taking a leukemia chemotherapy drug may help breast cancer patients who don't respond to tamoxifen overcome resistance to the widely-used drug, new research from the Kimmel Cancer Center at Jefferson suggests. ...
Cancer
Aug 01, 2011 |
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AMPK amplifies Huntington's disease
A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington's disease (HD). The article appears online on July 18, 2011, in The Journal of Cell Biology.
Medical research
Jul 18, 2011 |
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EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy
In the first phase III study to include Western lung cancer patients, first-line treatment with erlotinib (Tarceva) nearly doubled progression-free survival compared with chemotherapy, according to research presented at the ...
Cancer
Jul 05, 2011 |
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PET scan with [11C]erlotinib may provide noninvasive method to identify TKI-responsive lung tumors
A non-invasive PET imaging technique may identify lung cancers that respond best to tyrosine kinase inhibitors (TKIs), allowing doctors to better select patients for personalized therapy, according to research presented at ...
Cancer
Jul 05, 2011 |
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Patients treated with sunitinib and sorafenib respond to flu vaccine
Patients treated with sunitinib and sorafenib responded to the flu vaccine, which suggests the agents do not damage the immune system as much as previously feared, according to a study in Clinical Cancer Research, a journa ...
Cancer
Jun 28, 2011 |
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In search of the memory molecule, a key protein complex discovered
Have a tough time remembering where you put your keys, learning a new language or recalling names at a cocktail party? New research from the Lisman Laboratory at Brandeis University points to a molecule that is central to ...
Neuroscience
Jun 23, 2011 |
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