Medical research

New computational method exploits the polypharmacology of drugs

(Medical Xpress)—If life were simple, a disease could be treated with one drug that hits one molecular target, like striking a piano key. Instead, researchers wrestle with the fact that most drugs hit multiple targets in ...

Neuroscience

How neurons get wired

Two different versions of the same signaling protein tell a nerve cell which end is which, UA researchers have discovered. The findings could help improve therapies for spinal injuries and neurodegenerative diseases.

Medical research

New drug may protect the heart during ischemia

Research from three Yale laboratories—in the fields of immunobiology, chemistry, and cardiology—could lead to new drugs to reduce complications during cardiac surgery or heart attacks. If they pan out in human trials, ...

Neuroscience

Neuronal regeneration and the two-part design of nerves

Researchers at the University of Michigan have evidence that a single gene controls both halves of nerve cells, and their research demonstrates the need to consider that design in the development of new treatments for regeneration ...

Oncology & Cancer

Study identifies new drug target in deadly form of leukemia

A research team led by the Duke-NUS Graduate Medical School (Duke-NUS) in Singapore has identified ways to inhibit the function of a key protein linked to stem cell-like behavior in terminal-stage chronic myeloid leukemia ...

Genetics

Genetic mutation linked with typical form of migraine

A research team led by a Howard Hughes Medical Institute investigator at the University of California, San Francisco has identified a genetic mutation that is strongly associated with a typical form of migraine.

Oncology & Cancer

Cancer cell metabolism kills

Adenosine-5'-triphosphate (ATP) is the main energy source for all forms of work inside our cells. Scientists from the University of Helsinki, Finland, have found that even a short-term shortage of ATP supply can be fatal ...

Neuroscience

Scientists identify brain's 'molecular memory switch'

Scientists have identified a key molecule responsible for triggering the chemical processes in our brain linked to our formation of memories. The findings, published in the journal Frontiers in Neural Circuits, reveal a new ...

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