News tagged with knockout mice
Researchers identify critical link in mammalian odor detection
Researchers at the Monell Center and collaborators have identified a protein that is critical to the ability of mammals to smell. Mice engineered to be lacking the Ggamma13 protein in their olfactory receptors were functionally ...
Neuroscience
May 06, 2013 |
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Study finds key protein for firing up central nervous system inflammation
Scientists have identified an influential link in a chain of events that leads to autoimmune inflammation of the central nervous system in a mouse model of multiple sclerosis (MS).
Medical research
May 02, 2013 |
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Researchers decode a kind of trigger switch for the conversion of fat cells
For a long time, scientists have dreamed of converting undesirable white fat cells into brown fat cells and thus simply have excess pounds melt away. Researchers at the University of Bonn have now gotten ...
Medical research
Apr 23, 2013 |
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Researchers identify and block protein that interferes with appetite-suppressing hormone
Ever since the appetite-regulation hormone called leptin was discovered in 1994, scientists have sought to understand the mechanisms that control its action. It was known that leptin was made by fat cells, reduced appetite ...
Medical research
Apr 17, 2013 |
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Cell-permeable peptide shows promise for controlling cardiovascular disease
Atherosclerosis – sometimes called "hardening of the arteries" – is a leading cause of death and morbidity in Western countries. A cell-permeable peptide containing the NF-kB nuclear localization sequence (NLS) shows ...
Cardiology
Apr 17, 2013 |
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Study could aid development of new drugs to treat gout
Findings from a Loyola University Chicago Stritch School of Medicine study could lead to the development of new drugs to treat gout. The study, led by Liang Qiao, MD, and his colleagues and collaborators, was published March ...
Immunology
Mar 19, 2013 |
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Progesterone may be why pregnant women are more vulnerable to certain infections
Women who are pregnant or using synthetic progesterone birth control injections have a conspicuous vulnerability to certain infections including malaria, Listeria, HIV, and herpes simplex virus. A new research report appearing ...
Medical research
Feb 28, 2013 |
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Scientists find protein that reins in runaway network
Marked for death with molecular tags that act like a homing signal for a cell's protein-destroying machinery, a pivotal enzyme is rescued by another molecule that sweeps the telltale targets off in the nick of time.
Medical research
Jan 22, 2013 |
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Telmisartan reverses insulin resistance in mice
(HealthDay)—Treating mice fed a high-fat diet with telmisartan reverses insulin resistance and glucose intolerance, but only when the peroxisome proliferator-activated receptor-δ (PPAR-δ) gene is present, ...
Diabetes
Jan 03, 2013 |
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Research opens up possibility of therapies to restore blood-brain barrier
(Medical Xpress)—Research led by Queen Mary, University of London, has opened up the possibility that drug therapies may one day be able to restore the integrity of the blood-brain barrier, potentially ...
Medical research
Jan 02, 2013 |
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Lactation protein suppresses tumors and metastasis in breast cancer, scientists discover
A protein that is necessary for lactation in mammals inhibits the critical cellular transition that is an early indicator of breast cancer and metastasis, according to research conducted at the University at Buffalo and Princeton ...
Cancer
Oct 24, 2012 |
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Knockout finding reveals large number of genes that affect our bones
(Medical Xpress) -- Australian and UK scientists have shown that a large percentage of genes are likely to affect bone strength, potentially around 2,000 of the 21,000 genes in our bodies.
Genetics
Aug 08, 2012 |
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Researchers discover molecular link between circadian clock disturbances and inflammatory diseases
Scientists have known for some time that throwing off the body's circadian rhythm can negatively affect body chemistry. In fact, workers whose sleep-wake cycles are disrupted by night shifts are more susceptible to chronic ...
Medical research
Aug 01, 2012 |
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Liver fat gets a wake-up call that maintains blood sugar levels
A Penn research team, led by Mitchell Lazar, MD, PhD, director of the Institute for Diabetes, Obesity, and Metabolism at the Perelman School of Medicine, University of Pennsylvania, reports in Nature Medicine that m ...
Medical research
May 06, 2012 |
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Study may offer clues to reverse cognitive deficits in humans
The ability to navigate using spatial cues was impaired in mice whose brains were minus a channel that delivers potassium — a finding that may have implications for humans with damage to the hippocampus, a brain structure ...
Psychology & Psychiatry
Apr 26, 2012 |
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