One of the most common brain cancers in children, Sonic Hedgehog (SHH) medulloblastoma, also is one of the more survivable for most kids. Unfortunately, for a subset of patients the cancer resists treatment and relapses with ...
Aug 29, 2019
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Cancer immunotherapies have given patients with particularly intractable cancers new hope, but not everyone benefits. One such immunotherapy, known as CAR T-cell therapy, works only in about a third of the people who take ...
Aug 28, 2019
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Persistent pain, particularly neuropathic pain (NP), is a major health problem triggered by damage to or malfunction of the nervous system or by chronic diseases such as diabetes and multiple sclerosis. NP is seen as a sizable ...
Aug 15, 2019
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Scientists using an experimental treatment have slowed the progression of scrapie, a degenerative central nervous disease caused by prions, in laboratory mice and greatly extended the rodents' lives, according to a new report ...
Aug 2, 2019
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Allergies can be life-threatening when they cause anaphylaxis, an extreme reaction with constriction of the airways and a sudden drop in blood pressure. Scientists have identified a subtype of immune cell that drives the ...
Aug 1, 2019
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Researchers at the National Institutes of Health developed a new mouse model that could improve the translation of research in mice into advances in human health. The mouse model, which the scientists called "wildling," acquired ...
Aug 1, 2019
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A new study by scientists at Massachusetts General Hospital (MGH) offers clues about how to prevent inflammation of brain tissue, which promotes Alzheimer's disease (AD). The findings of this study online now and appearing ...
Jul 11, 2019
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Sortilin, which is a protein expressed on the surface of nerve cells, plays a crucial role in pain development in laboratory mice—and in all likelihood in humans as well. This is the main conclusion of the study "Sortilin ...
Jun 20, 2019
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Intestinal infection with helminths—a class of worm-like parasites—prevented weight gain in laboratory mice on a high-fat diet. The helminths did so by boosting populations of bacteria that produce compounds that trigger ...
Apr 8, 2019
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A new study provides critical insight into a little-known, yet relatively common, inherited neurological condition called Charcot-Marie-Tooth disease. The findings point to a pathway to possible treatments for this disease ...
Apr 4, 2019
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