Acute myeloid leukemia (AML) is an aggressive cancer of white blood cells with few effective targeted therapies available to treat it. Cold Spring Harbor Laboratory (CSHL) Professor Christopher Vakoc and former graduate student ...
Jan 11, 2022
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Aberrant splicing of messenger RNAs encoding surface antigen CD22 leads to downregulation of this protein in pediatric B-lymphoblastic leukemia (B-ALL), rendering malignant cells resistant to the effects of CD22-directed ...
Jan 4, 2022
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A molecular building block of many animal proteins, the amino acid valine, plays a key role in cancerous growth seen in T cell acute lymphoblastic leukemia, a new study shows.
Dec 22, 2021
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A unique collection of tissue samples donated by people with chronic myeloid leukemia was the driving force behind the discovery of a potentially major new treatment approach for drug-resistant leukemia. As published this ...
Dec 21, 2021
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An immunotherapy harnessing the immune system's "natural killer" cells has proven effective in treating acute myeloid leukemia (AML) in some adults whose cancers return. Now, researchers at Washington University School of ...
Dec 14, 2021
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Scientists at St. Jude Children's Research Hospital have a new understanding of how a group of well-known fusion oncoproteins causes leukemia. The findings show the importance of liquid-liquid phase separation (LLPS), a process ...
Dec 13, 2021
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Mutations in the enzyme IDH (isocitrate dehydrogenase) are found in 15–20% of acute myeloid leukemia (AML) cases. IDH mutations have been shown to impact cellular differentiation and DNA and histone methylation, but little ...
Dec 13, 2021
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An international team has developed statistical models to predict the risk of early death in patients being treated with non-intensive therapies for acute myeloid leukemia (AML). Results of analyses using the models will ...
Dec 12, 2021
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Researchers at Karolinska Institutet, University of Oslo and Oslo University Hospital have developed a new kind of immunotherapy for leukemia. The results of a study published in Nature Biotechnology show that the therapy ...
Dec 6, 2021
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Even within a single patient with cancer, there is a vast diversity of individual tumor cells, which display distinct behaviors related to growth, metastasis, and responses to chemotherapy. To carry out these behaviors, each ...
Nov 11, 2021
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