Medical research

Cholesterol levels sustainably lowered using base editing

Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team led by the University ...

Medical research

Lipid droplets help protect kidney cells from damage

Researchers at the Francis Crick Institute have found out how microscopic structures called lipid droplets may help to prevent a high-fat diet causing kidney damage. The work in fruit flies, published in PLoS Biology opens ...

Medical research

New statistical method eases data reproducibility crisis

A reproducibility crisis is ongoing in scientific research, where many studies may be difficult or impossible to replicate and thereby validate, especially when the study involves a very large sample size. For example, to ...

Medical research

Store fat or burn it? Targeting a single protein flips the switch

As obesity becomes a growing issue worldwide—nearly tripling over the last-half century—scientists are trying to gain a better understanding of the condition at the molecular level. Now, new research led by UC San Francisco ...

Neuroscience

Lipid epoxides target pain, inflammatory pathways in neurons

When modified using a process known as epoxidation, two naturally occurring lipids are converted into potent agents that target multiple cannabinoid receptors in neurons, interrupting pathways that promote pain and inflammation, ...

Oncology & Cancer

Map shows how cancer cells spread through the body

The vast majority of cancer deaths are attributed to metastasis, or the spread of tumors from one organ to another. Determining if a cancer will metastasize has been all but impossible, but if it does, it becomes more difficult ...

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